Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.
Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs, respectively) regulate numerous cell surface signaling events, with typically opposite effects on cell function. CSPGs inhibit nerve regeneration through receptor protein tyrosine phosphatase sigma (RPTPσ). Here we report that RPTPσ act...
المؤلفون الرئيسيون: | Coles, C, Shen, Y, Tenney, A, Siebold, C, Sutton, G, Lu, W, Gallagher, J, Jones, E, Flanagan, J, Aricescu, A |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2011
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مواد مشابهة
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Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension
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Novel RPTPγ and RPTPζ splice variants from mixed neuron–astrocyte hippocampal cultures as well as from the hippocampi of newborn and adult mice
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Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity
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LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate
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