Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase

Bibliografiske detaljer
Main Authors:	Kavanagh, K, Guo, K, Wu, X, Knapp, S, Ebetino, F, Dunford, J, Rogers, M, Russell, R, Oppermann, U
Format:	Conference item
Udgivet:	2006

Lignende værker

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
af: Kavanagh, K, et al.
Udgivet: (2005)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
af: Dunford, J, et al.
Udgivet: (2006)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
af: Evdokimov, A, et al.
Udgivet: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
af: Ebetino, F, et al.
Udgivet: (2006)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
af: Ebetino, F, et al.
Udgivet: (2002)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
af: Ebetino, F, et al.
Udgivet: (2006)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
af: Ebetino, F, et al.
Udgivet: (2005)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
af: Heloisa B Gabriel, et al.
Udgivet: (2018-08-01)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
af: Dunford, J, et al.
Udgivet: (2006)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
af: Xia, Z, et al.
Udgivet: (2007)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
af: Ebetino, F, et al.
Udgivet: (2007)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
af: Ebetino, F, et al.
Udgivet: (2002)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
af: Ebetino, F, et al.
Udgivet: (2002)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
af: Dunford, J, et al.
Udgivet: (2007)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
af: Ebetino, F, et al.
Udgivet: (2006)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
af: Dunford, J, et al.
Udgivet: (2007)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
af: Dunford, J, et al.
Udgivet: (2008)

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates
af: Dunford, J, et al.
Udgivet: (2008)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
af: Dunford, J, et al.
Udgivet: (2008)

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
af: Kwassi, A, et al.
Udgivet: (2009)

Alendronate and ibandronate affect osteoclast formation and size differently from risedronate and zoledronate
af: Mabilleau, G, et al.
Udgivet: (2011)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
af: Dunford, J, et al.
Udgivet: (2008)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
af: Xia, Z, et al.
Udgivet: (2006)

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
af: Dunford, J, et al.
Udgivet: (2008)

Molecular characterization of ginseng farnesyl diphosphate synthase gene and its up-regulation by methyl jasmonate
af: O. T. Kim, et al.
Udgivet: (2010-03-01)

Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z‑Farnesyl Diphosphate Synthase
af: Yueh-Te Chan, et al.
Udgivet: (2017-03-01)

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
af: Daoyong Gong, et al.
Udgivet: (2022-10-01)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
af: Ebetino, F, et al.
Udgivet: (2007)

Molecular cloning and characterization of farnesyl diphosphate synthase from Rosa rugosa Thunb associated with salinity stress
af: Guo Wei, et al.
Udgivet: (2024-02-01)

Functional characterization and transcriptional activity analysis of Dryopteris fragrans farnesyl diphosphate synthase genes
af: Dongrui Zhang, et al.
Udgivet: (2023-03-01)

Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-<i>Trypanosomatidae</i> Drug Discovery
af: Boniface Pone Kamdem, et al.
Udgivet: (2023-08-01)

Identification of a novel class of ω,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis
af: Rakesh K. Dhiman, et al.
Udgivet: (2004-06-01)

FARNESYL DIPHOSPHATE SYNTHASE (FDRS) AND GERANYLGERANYL DIPHOSPHATE SYNTHASE (GGSP1) GENE POLYMORPHISMS AND EFFICIENCY OF THERAPY WITH BISPHOSPHONATES IN RUSSIAN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A PILOT STUDY
af: M. Yu. Krylov, et al.
Udgivet: (2016-03-01)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
af: Tsoumpra, M, et al.
Udgivet: (2010)

Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia
af: Ana Paula R. Gadelha, et al.
Udgivet: (2020-04-01)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
af: Tsoumpra, M, et al.
Udgivet: (2015)

Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
af: Tingting Jin, et al.
Udgivet: (2022-08-01)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
af: Tsoumpra, MK, et al.
Udgivet: (2015)

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
af: Kavanagh, K, et al.
Udgivet: (2006)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
af: Nguyen Thi Ha, et al.
Udgivet: (2020-10-01)