Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children
One in 400 people has a maternally inherited mutation in mtDNA potentially causing incurable disease. In so-called heteroplasmic disease, mutant and normal mtDNA co-exist in the cells of carrier women. Disease severity depends on the proportion of inherited abnormal mtDNA molecules. Families who hav...
Main Authors: | Diot, A, Dombi, E, Lodge, T, Liao, C, Morten, K, Carver, J, Wells, D, Child, T, Johnston, I, Williams, S, Poulton, J |
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Format: | Journal article |
Language: | English |
Published: |
Portland Press
2016
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