Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is known about their etiology and pathogenesis. We previously mapped a gene that predisposes to multiple fibroids, cutaneous leiomyomata and renal cell carcinoma to chromosome 1q42.3-q43 (refs 4-6). Here we show, t...

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Bibliographic Details
Main Authors: Tomlinson, I, Alam, N, Rowan, A, Barclay, E, Jaeger, E, Kelsell, D, Leigh, I, Gorman, P, Lamlum, H, Rahman, S, Roylance, R, Olpin, S, Bevan, S, Barker, K, Hearle, N, Houlston, R, Kiuru, M, Lehtonen, R, Karhu, A, Vilkki, S, Laiho, P, Eklund, C, Vierimaa, O, Aittomäki, K, Hietala, M
Format: Journal article
Language:English
Published: 2002

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