Mechanistic roles of protein disorder within transcription
Understanding the interactions of proteins involved in transcriptional regulation is critical to describing biological systems because they control the expression profile of the cell. Yet sadly they belong to a less well biophysically characterized subset of proteins; they frequently contain long...
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| Format: | Journal article |
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Elsevier
2017
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| _version_ | 1826259804525428736 |
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| author | Shammas, S |
| author_facet | Shammas, S |
| author_sort | Shammas, S |
| collection | OXFORD |
| description | Understanding the interactions of proteins involved in transcriptional regulation is critical to describing biological systems because they control the expression profile of the cell. Yet sadly they belong to a less well biophysically characterized subset of proteins; they frequently contain long disordered regions that are highly dynamic. A key question therefore is, why? What functional roles does protein disorder play in transcriptional regulation? Experimental data exemplifying these roles are starting to emerge, with common themes being enabling complexity within networks and quick responses. Most recently a role for disorder in mediating phase transitions of membrane-less organelles has been proposed. |
| first_indexed | 2024-03-06T18:55:35Z |
| format | Journal article |
| id | oxford-uuid:11b6ab82-84ee-45df-ae25-f15730ff6f5d |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:55:35Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:11b6ab82-84ee-45df-ae25-f15730ff6f5d2022-03-26T10:03:51ZMechanistic roles of protein disorder within transcriptionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:11b6ab82-84ee-45df-ae25-f15730ff6f5dSymplectic Elements at OxfordElsevier2017Shammas, SUnderstanding the interactions of proteins involved in transcriptional regulation is critical to describing biological systems because they control the expression profile of the cell. Yet sadly they belong to a less well biophysically characterized subset of proteins; they frequently contain long disordered regions that are highly dynamic. A key question therefore is, why? What functional roles does protein disorder play in transcriptional regulation? Experimental data exemplifying these roles are starting to emerge, with common themes being enabling complexity within networks and quick responses. Most recently a role for disorder in mediating phase transitions of membrane-less organelles has been proposed. |
| spellingShingle | Shammas, S Mechanistic roles of protein disorder within transcription |
| title | Mechanistic roles of protein disorder within transcription |
| title_full | Mechanistic roles of protein disorder within transcription |
| title_fullStr | Mechanistic roles of protein disorder within transcription |
| title_full_unstemmed | Mechanistic roles of protein disorder within transcription |
| title_short | Mechanistic roles of protein disorder within transcription |
| title_sort | mechanistic roles of protein disorder within transcription |
| work_keys_str_mv | AT shammass mechanisticrolesofproteindisorderwithintranscription |