Sub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materials
Future progress in materials for tissue engineering and 3D cell cultures applications requires control of two key physical properties: nanoscale mechanical properties and mass transport. These requirements remain uncontrolled partly due to a lack of physical parameters and quantitative measurements....
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Published: |
Royal Society of Chemistry
2015
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| _version_ | 1826259810647015424 |
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| author | Axpe, E Bugnicourt, L Merida, D Goiriena-Goikoetxea, M Unzueta, I Sanchez-Eugenia, R Garcia, J Plazaola, F Contera, S |
| author_facet | Axpe, E Bugnicourt, L Merida, D Goiriena-Goikoetxea, M Unzueta, I Sanchez-Eugenia, R Garcia, J Plazaola, F Contera, S |
| author_sort | Axpe, E |
| collection | OXFORD |
| description | Future progress in materials for tissue engineering and 3D cell cultures applications requires control of two key physical properties: nanoscale mechanical properties and mass transport. These requirements remain uncontrolled partly due to a lack of physical parameters and quantitative measurements. Using chitosan scaffolds as a model system in close-to-physiological conditions and a combination of experimental techniques and theory, we link structure with local nanomechanical properties. Additionally we introduce a parameter, the free volume, to predict variations in transport properties. By fabricating nanocomposites with single walled carbon nanotubes (SWNTs) we are able to test our approach: incorporation of acid-treated, soluble, [similar]80 nm SWNTs in a chitosan matrix leads to a 2 fold increase in mean local elastic modulus and a decrease of 3% of the free volume available for oxygen diffusion. Inclusion of hydrophobic, [similar]800 nm SWNTs leads to a 100 fold increase of elastic modulus and doubles the voids percentage available for the transport of glucose. |
| first_indexed | 2024-03-06T18:55:41Z |
| format | Journal article |
| id | oxford-uuid:11c1dddf-c6e8-4b4d-b324-48acd246bb29 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:55:41Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:11c1dddf-c6e8-4b4d-b324-48acd246bb292022-03-26T10:04:03ZSub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materialsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:11c1dddf-c6e8-4b4d-b324-48acd246bb29Symplectic Elements at OxfordRoyal Society of Chemistry2015Axpe, EBugnicourt, LMerida, DGoiriena-Goikoetxea, MUnzueta, ISanchez-Eugenia, RGarcia, JPlazaola, FContera, SFuture progress in materials for tissue engineering and 3D cell cultures applications requires control of two key physical properties: nanoscale mechanical properties and mass transport. These requirements remain uncontrolled partly due to a lack of physical parameters and quantitative measurements. Using chitosan scaffolds as a model system in close-to-physiological conditions and a combination of experimental techniques and theory, we link structure with local nanomechanical properties. Additionally we introduce a parameter, the free volume, to predict variations in transport properties. By fabricating nanocomposites with single walled carbon nanotubes (SWNTs) we are able to test our approach: incorporation of acid-treated, soluble, [similar]80 nm SWNTs in a chitosan matrix leads to a 2 fold increase in mean local elastic modulus and a decrease of 3% of the free volume available for oxygen diffusion. Inclusion of hydrophobic, [similar]800 nm SWNTs leads to a 100 fold increase of elastic modulus and doubles the voids percentage available for the transport of glucose. |
| spellingShingle | Axpe, E Bugnicourt, L Merida, D Goiriena-Goikoetxea, M Unzueta, I Sanchez-Eugenia, R Garcia, J Plazaola, F Contera, S Sub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materials |
| title | Sub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materials |
| title_full | Sub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materials |
| title_fullStr | Sub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materials |
| title_full_unstemmed | Sub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materials |
| title_short | Sub-nanoscale free volume and local elastic modulus of chitosan–carbon nanotube biomimetic nanocomposite scaffold-materials |
| title_sort | sub nanoscale free volume and local elastic modulus of chitosan carbon nanotube biomimetic nanocomposite scaffold materials |
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