Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

A small series of aminobisphosphonates (N-BPs) structurally related to zoledronic acid was synthesized with the aim of improving activity toward activation of human gammadelta T cells and in turn their in vivo antitumor activity. The absence of the 1-OH moiety, together with the position and the dif...

Bibliografski detalji
Glavni autori:	Simoni, D, Gebbia, N, Invidiata, F, Eleopra, M, Marchetti, P, Rondanin, R, Baruchello, R, Provera, S, Marchioro, C, Tolomeo, M, Marinelli, L, Limongelli, V, Novellino, E, Kwaasi, A, Dunford, J, Buccheri, S, Caccamo, N, Dieli, F
Format:	Journal article
Jezik:	English
Izdano:	2008

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