The new immunosuppression.
New knowledge on how lymphocytes become tolerant to antigens is now enabling novel tolerance-harnessing strategies to enter the clinical arena. In the field of transplantation, monoclonal antibodies used either to deplete lymphocytes or to block T-cell function can induce tolerance in mice and non-h...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1826259827672743936 |
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| author | Waldmann, H |
| author_facet | Waldmann, H |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | New knowledge on how lymphocytes become tolerant to antigens is now enabling novel tolerance-harnessing strategies to enter the clinical arena. In the field of transplantation, monoclonal antibodies used either to deplete lymphocytes or to block T-cell function can induce tolerance in mice and non-human primates. Understanding the mechanisms underlying tolerance should enable application to the clinic. Harnessing of tolerance mechanisms may enable more judicious use of conventional immunosuppressive agents even to the point of maintenance monotherapy, so limiting drug side effects and ensuring compliance. |
| first_indexed | 2024-03-06T18:55:57Z |
| format | Journal article |
| id | oxford-uuid:11d8e59d-b3b3-4a78-be7c-e076068abd92 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:55:57Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:11d8e59d-b3b3-4a78-be7c-e076068abd922022-03-26T10:04:30ZThe new immunosuppression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:11d8e59d-b3b3-4a78-be7c-e076068abd92EnglishSymplectic Elements at Oxford2003Waldmann, HNew knowledge on how lymphocytes become tolerant to antigens is now enabling novel tolerance-harnessing strategies to enter the clinical arena. In the field of transplantation, monoclonal antibodies used either to deplete lymphocytes or to block T-cell function can induce tolerance in mice and non-human primates. Understanding the mechanisms underlying tolerance should enable application to the clinic. Harnessing of tolerance mechanisms may enable more judicious use of conventional immunosuppressive agents even to the point of maintenance monotherapy, so limiting drug side effects and ensuring compliance. |
| spellingShingle | Waldmann, H The new immunosuppression. |
| title | The new immunosuppression. |
| title_full | The new immunosuppression. |
| title_fullStr | The new immunosuppression. |
| title_full_unstemmed | The new immunosuppression. |
| title_short | The new immunosuppression. |
| title_sort | new immunosuppression |
| work_keys_str_mv | AT waldmannh thenewimmunosuppression AT waldmannh newimmunosuppression |