A new organocatalytic desymmetrization reaction enables the enantioselective total synthesis of madangamine E

The enantioselective total synthesis of madangamine E has been completed in 30 steps, enabled by a new catalytic and highly enantioselective desymmetrizing intramolecular Michael addition reaction of a prochiral ketone to a tethered β,β′-disubstituted nitroolefin. This key carbon–carbon bond forming...

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Библиографические подробности
Главные авторы: Shiomi, S, Shennan, BDA, Yamazaki, K, Fuentes de Arriba, ÁL, Vasu, D, Hamlin, TA, Dixon, DJ
Формат: Journal article
Язык:English
Опубликовано: American Chemical Society 2022