Piperidine analogues of D-galactose as potent inhibitors of alpha-galactosidase: Synthesis by stannane-mediated hydroxymethylation of 5-azido-1,4-lactones. Structural relationships between D-galactosidase and L-rhamnosidase inhibitors

The syntheses of the polyhydroxylated piperidines deoxygalactonojirimycin 2, homogalactonojirimycins 7 and 9, and other 2,6-iminoheptitol derivatives, including an analogue of L-altropyranose, are reported. 5-Azidoaldono1,4-lactones undergo chain extension to afford azido lactols by the addition of...

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Những tác giả chính: Shilvock, J, Nash, R, Watson, A, Winters, A, Butters, T, Dwek, R, Winkler, D, Fleet, G
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1999