Piperidine analogues of D-galactose as potent inhibitors of alpha-galactosidase: Synthesis by stannane-mediated hydroxymethylation of 5-azido-1,4-lactones. Structural relationships between D-galactosidase and L-rhamnosidase inhibitors
The syntheses of the polyhydroxylated piperidines deoxygalactonojirimycin 2, homogalactonojirimycins 7 and 9, and other 2,6-iminoheptitol derivatives, including an analogue of L-altropyranose, are reported. 5-Azidoaldono1,4-lactones undergo chain extension to afford azido lactols by the addition of...
Κύριοι συγγραφείς: | Shilvock, J, Nash, R, Watson, A, Winters, A, Butters, T, Dwek, R, Winkler, D, Fleet, G |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
1999
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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The synthesis of deoxygalactostatin and 2,6 imino-heptitol derivatives via stannane mediated hydroxymethylation of 5-azido-1,4-lactones
ανά: Shilvock, J, κ.ά.
Έκδοση: (1998) -
Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-lyxitol [a potent competitive inhibitor of alpha-D-galactosidase] and of 1,4-dideoxy-1,4-imino-L-lyxitol [a weak competitive inhibitor of alpha-D-galactosidase] inhibit naringinase, an alpha-L-rhamnosidase competitively
ανά: Mercer, T, κ.ά.
Έκδοση: (2009) -
Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors
ανά: Georg Schitter, κ.ά.
Έκδοση: (2010-03-01) -
Synthesis of homorhamnojirimycins and related trihydroxypipecolic acid derivatives via divergent bicyclic amino lactone intermediates: Inhibition of naringinase (L-rhamnosidase) and dTDP-rhamnose biosynthesis
ανά: Shilvock, J, κ.ά.
Έκδοση: (1999) -
Hydrolysis of lactose with -D-galactosidase
ανά: Vesna Stehlik-Tomas, κ.ά.
Έκδοση: (2001-06-01)