Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.

Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.

The binding of HIV-derived recombinant soluble (s)gp120 to the CD4(+)/CXCR4(+) A3.01 T cell line inhibits the binding of the CXCR4-specific monoclonal antibodies 12G5, which interacts with the second extracellular loop, and 6H8, which binds the NH2 terminus. We have used this as an assay to analyse...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Mondor, I, Moulard, M, Ugolini, S, Klasse, P, Hoxie, J, Amara, A, Delaunay, T, Wyatt, R, Sodroski, J, Sattentau, Q
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1998

Eitemau Tebyg

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