CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS
Both 5R- and 5S-5-amino-5-carboxy-2-oxapentanoyl side chains can substitute for the L-δ-α-aminoadipoyl side chain in the isopenicillin N synthase catalysed formation of penicillins from tripeptides. The 5R- side chain analogue can be cleaved from penicillins and cephalosporins by treatment with D-am...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1995
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| _version_ | 1826259891646365696 |
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| author | Baldwin, J Davis, S Forrest, A Schofield, C |
| author_facet | Baldwin, J Davis, S Forrest, A Schofield, C |
| author_sort | Baldwin, J |
| collection | OXFORD |
| description | Both 5R- and 5S-5-amino-5-carboxy-2-oxapentanoyl side chains can substitute for the L-δ-α-aminoadipoyl side chain in the isopenicillin N synthase catalysed formation of penicillins from tripeptides. The 5R- side chain analogue can be cleaved from penicillins and cephalosporins by treatment with D-amino acid oxidase followed by oxidative decarboxylation and decarboxylative elimination. © 1995. |
| first_indexed | 2024-03-06T18:56:59Z |
| format | Journal article |
| id | oxford-uuid:122c8961-226b-4349-9edf-5fc0a8893075 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:56:59Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:122c8961-226b-4349-9edf-5fc0a88930752022-03-26T10:06:28ZCLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINSJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:122c8961-226b-4349-9edf-5fc0a8893075EnglishSymplectic Elements at Oxford1995Baldwin, JDavis, SForrest, ASchofield, CBoth 5R- and 5S-5-amino-5-carboxy-2-oxapentanoyl side chains can substitute for the L-δ-α-aminoadipoyl side chain in the isopenicillin N synthase catalysed formation of penicillins from tripeptides. The 5R- side chain analogue can be cleaved from penicillins and cephalosporins by treatment with D-amino acid oxidase followed by oxidative decarboxylation and decarboxylative elimination. © 1995. |
| spellingShingle | Baldwin, J Davis, S Forrest, A Schofield, C CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS |
| title | CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS |
| title_full | CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS |
| title_fullStr | CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS |
| title_full_unstemmed | CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS |
| title_short | CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS |
| title_sort | cleavage of the 5 amino 5 carboxy 2 oxapentanoyl side chain from enzymatically synthesized penicillins and cephalosporins |
| work_keys_str_mv | AT baldwinj cleavageofthe5amino5carboxy2oxapentanoylsidechainfromenzymaticallysynthesizedpenicillinsandcephalosporins AT daviss cleavageofthe5amino5carboxy2oxapentanoylsidechainfromenzymaticallysynthesizedpenicillinsandcephalosporins AT forresta cleavageofthe5amino5carboxy2oxapentanoylsidechainfromenzymaticallysynthesizedpenicillinsandcephalosporins AT schofieldc cleavageofthe5amino5carboxy2oxapentanoylsidechainfromenzymaticallysynthesizedpenicillinsandcephalosporins |