CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS
Both 5R- and 5S-5-amino-5-carboxy-2-oxapentanoyl side chains can substitute for the L-δ-α-aminoadipoyl side chain in the isopenicillin N synthase catalysed formation of penicillins from tripeptides. The 5R- side chain analogue can be cleaved from penicillins and cephalosporins by treatment with D-am...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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