Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy
The hydroxide-driven dissolution of the polymer hydroxypropyl methylcellulose phthalate (HPMCP) in aqueous solution is studied using atomic force microscopy. The novel technique of employing the surface-averaged z-piezo voltage as a direct measure of the mean absolute surface height is described, so...
| Päätekijät: | , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
1997
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| _version_ | 1826259903337988096 |
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| author | Sanders, G Booth, J Compton, R |
| author_facet | Sanders, G Booth, J Compton, R |
| author_sort | Sanders, G |
| collection | OXFORD |
| description | The hydroxide-driven dissolution of the polymer hydroxypropyl methylcellulose phthalate (HPMCP) in aqueous solution is studied using atomic force microscopy. The novel technique of employing the surface-averaged z-piezo voltage as a direct measure of the mean absolute surface height is described, so as, after appropriate calibration, to permit the ready inference of dissolution fluxes. In the case of interest the following dissolution rate law was established: j/g·cm-2·s-1 = 105.0[OH-] over the pH range 8.0-9.2, where j is the flux of the dissolving polymer and [OH-] is measured in mol cm-3. |
| first_indexed | 2024-03-06T18:57:10Z |
| format | Journal article |
| id | oxford-uuid:123d909e-a5a8-4364-a36c-1c5940421276 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:57:10Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:123d909e-a5a8-4364-a36c-1c59404212762022-03-26T10:06:47ZQuantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:123d909e-a5a8-4364-a36c-1c5940421276EnglishSymplectic Elements at Oxford1997Sanders, GBooth, JCompton, RThe hydroxide-driven dissolution of the polymer hydroxypropyl methylcellulose phthalate (HPMCP) in aqueous solution is studied using atomic force microscopy. The novel technique of employing the surface-averaged z-piezo voltage as a direct measure of the mean absolute surface height is described, so as, after appropriate calibration, to permit the ready inference of dissolution fluxes. In the case of interest the following dissolution rate law was established: j/g·cm-2·s-1 = 105.0[OH-] over the pH range 8.0-9.2, where j is the flux of the dissolving polymer and [OH-] is measured in mol cm-3. |
| spellingShingle | Sanders, G Booth, J Compton, R Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy |
| title | Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy |
| title_full | Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy |
| title_fullStr | Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy |
| title_full_unstemmed | Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy |
| title_short | Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy |
| title_sort | quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy |
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