Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy
The hydroxide-driven dissolution of the polymer hydroxypropyl methylcellulose phthalate (HPMCP) in aqueous solution is studied using atomic force microscopy. The novel technique of employing the surface-averaged z-piezo voltage as a direct measure of the mean absolute surface height is described, so...
| Autors principals: | , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
1997
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