Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial

Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial

Show other versions (1)

Background: OXi4503 is a tubulin-binding vascular disrupting agent that has recently completed a Cancer Research UK-sponsored phase I trial. Preclinical studies demonstrated early drug-induced apoptosis in tumour endothelial cells at 1-3 h and secondary tumour cell necrosis between 6 and 72 h. Metho...

书目详细资料
Main Authors:	Cummings, J, Zweifel, M, Smith, N, Ross, P, Peters, J, Rustin, G, Price, P, Middleton, MR, Ward, T, Dive, C
格式:	Journal article
语言:	English
出版:	2012

相似书籍

Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial.
由: Cummings, J, et al.
出版: (2012)

Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors.
由: Patterson, D, et al.
出版: (2012)

Validation of a method for the determination of the anticancer agent Combretastatin A1 phosphate (CA1P, OXi4503) in human plasma by HPLC with post-column photolysis and fluorescence detection.
由: Stratford, MR, et al.
出版: (2011)

Validation of a method for the determination of the anticancer agent Combretastatin A1 phosphate (CA1P, OXi4503) in human plasma by HPLC with post-column photolysis and fluorescence detection
由: Stratford, M, et al.
出版: (2011)

4503 Adaptation of Motor Action in Children with Hemiplegic Cerebral Palsy
由: Katherine Dimitropoulou, et al.
出版: (2020-06-01)

Quantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection.
由: Stratford, MR, et al.
出版: (2012)

Use of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by Stilbenes.
由: Loai Basheer, et al.
出版: (2015-01-01)

Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents.
由: Shaked, Y, et al.
出版: (2009)

SA4503 Mitigates Adriamycin-Induced Nephropathy via Sigma-1 Receptor in Animal and Cell-Based Models
由: Hideaki Tagashira, et al.
出版: (2025-01-01)

Vascular disrupting agent drug classes differ in effects on the cytoskeleton.
由: Sujeong Kim, et al.
出版: (2012-01-01)

Risk assessment of drug–drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach
由: Yulia Vugmeyster, et al.
出版: (2022-12-01)

Tumour vascular disrupting agents: combating treatment resistance.
由: Tozer, G, et al.
出版: (2008)

Saint John's wort, an herbal inducer of the cytochrome P4503A4 isoform, may alleviate symptoms of Willis-Ekbom's disease
由: José Carlos Pereira Jr, et al.
出版: (2013-04-01)

Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite.
由: Varsha Agarwal, et al.
出版: (2008-06-01)

Corrigendum: The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism
由: Xin Liu, et al.
出版: (2022-04-01)

Limitation of Irregularities in Projects Co-financed by EU Funds. Gloss to the Judgement of the Supreme Administrative Court of 18 May 2017 (II GSK 4503/10)
由: Rafał Poździk
出版: (2020-06-01)

4-Hydr-oxy-3-nitro-benzaldehyde.
由: Rizal, M.R., et al.
出版: (2008)

Targeting vascular disrupting agent-treated tumor microenvironment with tissue-penetrating nanotherapy
由: Valeria Sidorenko, et al.
出版: (2024-07-01)

Parallel kinetic resolution of tert-butyl (RS)-3-oxy-substituted cyclopent-1-ene-carboxylates for the asymmetric synthesis of 3-oxy-substituted cispentacin and transpentacin derivatives.
由: Aye, Y, et al.
出版: (2008)

Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells
由: Frank Stappenbeck, et al.
出版: (2024-09-01)

1-De-oxy-l-mannitol (6-de-oxy-l-mannitol or l-rhamnitol).
由: Jenkinson, S, et al.
出版: (2008)

Antitumor effect of the vascular-disrupting agent ZD6126 in a murine renal cell carcinoma model.
由: Medinger, M, et al.
出版: (2011)

Quantifying the evolution of vascular barrier disruption in advanced atherosclerosis with semipermeant nanoparticle contrast agents.
由: Huiying Zhang, et al.
出版: (2011-01-01)

Oxy-Hydrogen Flame for Cutting of Steels
由: Tušek, J., et al.
出版: (2007-01-01)

Dynamic-Stability Characteristics of Premixed Methane Oxy-Combustion
由: Shroll, Andrew P, et al.
出版: (2021)

Neutrophil Influx and Chemokine Production during the Early Phases of the Antitumor Response to the Vascular Disrupting Agent DMXAA (ASA404)
由: Liang-Chuan S. Wang, et al.
出版: (2009-08-01)

Treatment Effect of a Vascular-Disrupting Agent Dynamically Monitored by DWI: An Animal Experimental Study
由: Danping Huang, et al.
出版: (2021-01-01)

Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent
由: Rickardson L, et al.
出版: (2017-04-01)

Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines
由: Hung Chien-Fu, et al.
出版: (2011-03-01)

Mechanisms of tumor resistance to small-molecule vascular disrupting agents: Treatment and rationale of combination therapy
由: Xue-Yuan Wu, et al.
出版: (2013-03-01)

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors
由: Li Liu, et al.
出版: (2021-04-01)

2-Hydroxy-5-nitrobenzaldehyde thiosemicarbazone
由: Alhadi, Abeer A., et al.
出版: (2008)

Resilience and ductility of Oxy-fuel HAZ cut
由: A. Martín-Meizoso,, et al.
出版: (2014-10-01)

Resilience and ductility of Oxy-fuel HAZ cut
由: A. Martín-Meizoso, et al.
出版: (2014-09-01)

Oxy-acetylene welding and cutting/
由: Giachino, Joseph William, 1906-
出版: (1942)

Oxy-Acetylene welding [filem]
出版: ([197)

Oxy-acetylene welding [videorecording]
由: Safetycare Australia
出版: (2010)

Oxy acetylene cutting [videorecording]
出版: (2010)

Oxy-acetylene welding handbook
出版: ([n d)

ẢNH HƯỞNG CỦA OXY HÒA TAN LÊN TĂNG TRƯỞNG, TIÊU HAO OXY VÀ NGƯỠNG OXY CỦA CÁ CHÉP (CYPRINUS CARPIO)
由: Nguyễn Thúy Liễu, et al.
出版: (2012-05-01)