Epithelial cell polarity: A major gatekeeper against cancer
The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation and excessive cell growth are hallmarks of cancer. In this review, we focus on identifying the stages of tumoural develo...
| Egile Nagusiak: | , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2011
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| _version_ | 1826259910538559488 |
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| author | Royer, C Lu, X |
| author_facet | Royer, C Lu, X |
| author_sort | Royer, C |
| collection | OXFORD |
| description | The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation and excessive cell growth are hallmarks of cancer. In this review, we focus on identifying the stages of tumoural development that are affected by the loss or deregulation of epithelial cell polarity. Asymmetric division has recently emerged as a major regulatory mechanism that controls stem cell numbers and differentiation. Links between cell polarity and asymmetric cell division in the context of cancer will be examined. Apical-basal polarity and cell-cell adhesion are tightly interconnected. Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed. Altogether, we present the argument that loss of epithelial cell polarity may have an important role in both the initiation of tumourigenesis and in later stages of tumour development, favouring the progression of tumours from benign to malignancy. © 2011 Macmillan Publishers Limited All rights reserved. |
| first_indexed | 2024-03-06T18:57:17Z |
| format | Journal article |
| id | oxford-uuid:124598a3-e726-4395-bfd8-0d82918a3b5d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:57:17Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:124598a3-e726-4395-bfd8-0d82918a3b5d2022-03-26T10:06:59ZEpithelial cell polarity: A major gatekeeper against cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:124598a3-e726-4395-bfd8-0d82918a3b5dEnglishSymplectic Elements at Oxford2011Royer, CLu, XThe correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation and excessive cell growth are hallmarks of cancer. In this review, we focus on identifying the stages of tumoural development that are affected by the loss or deregulation of epithelial cell polarity. Asymmetric division has recently emerged as a major regulatory mechanism that controls stem cell numbers and differentiation. Links between cell polarity and asymmetric cell division in the context of cancer will be examined. Apical-basal polarity and cell-cell adhesion are tightly interconnected. Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed. Altogether, we present the argument that loss of epithelial cell polarity may have an important role in both the initiation of tumourigenesis and in later stages of tumour development, favouring the progression of tumours from benign to malignancy. © 2011 Macmillan Publishers Limited All rights reserved. |
| spellingShingle | Royer, C Lu, X Epithelial cell polarity: A major gatekeeper against cancer |
| title | Epithelial cell polarity: A major gatekeeper against cancer |
| title_full | Epithelial cell polarity: A major gatekeeper against cancer |
| title_fullStr | Epithelial cell polarity: A major gatekeeper against cancer |
| title_full_unstemmed | Epithelial cell polarity: A major gatekeeper against cancer |
| title_short | Epithelial cell polarity: A major gatekeeper against cancer |
| title_sort | epithelial cell polarity a major gatekeeper against cancer |
| work_keys_str_mv | AT royerc epithelialcellpolarityamajorgatekeeperagainstcancer AT lux epithelialcellpolarityamajorgatekeeperagainstcancer |