FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms.
Planarians provide a relatively simple model system in which to study stem cell dynamics and regenerative phenomena. As with other systems understanding the dynamics of stem cell and stem cell progeny is crucial in order to get at the molecular mechanisms orchestrating stem cell biology. Planarians...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797054438232293376 |
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| author | Romero, B Evans, D Aboobaker, A |
| author_facet | Romero, B Evans, D Aboobaker, A |
| author_sort | Romero, B |
| collection | OXFORD |
| description | Planarians provide a relatively simple model system in which to study stem cell dynamics and regenerative phenomena. As with other systems understanding the dynamics of stem cell and stem cell progeny is crucial in order to get at the molecular mechanisms orchestrating stem cell biology. Planarians have an abundant adult stem cell population that can be observed using Fluorescence-Activated Cell Sorting (FACS). This approach allows different subpopulations of stem cells and their progeny to be monitored and sorted for downstream studies in response to different regenerative scenarios, drug treatments, or RNAi knockdown of genes required for regenerative events. |
| first_indexed | 2024-03-06T18:57:17Z |
| format | Journal article |
| id | oxford-uuid:1246065b-4ffb-46b0-8b2b-78d1234169ec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:57:17Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:1246065b-4ffb-46b0-8b2b-78d1234169ec2022-03-26T10:07:00ZFACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1246065b-4ffb-46b0-8b2b-78d1234169ecEnglishSymplectic Elements at Oxford2012Romero, BEvans, DAboobaker, APlanarians provide a relatively simple model system in which to study stem cell dynamics and regenerative phenomena. As with other systems understanding the dynamics of stem cell and stem cell progeny is crucial in order to get at the molecular mechanisms orchestrating stem cell biology. Planarians have an abundant adult stem cell population that can be observed using Fluorescence-Activated Cell Sorting (FACS). This approach allows different subpopulations of stem cells and their progeny to be monitored and sorted for downstream studies in response to different regenerative scenarios, drug treatments, or RNAi knockdown of genes required for regenerative events. |
| spellingShingle | Romero, B Evans, D Aboobaker, A FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms. |
| title | FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms. |
| title_full | FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms. |
| title_fullStr | FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms. |
| title_full_unstemmed | FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms. |
| title_short | FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms. |
| title_sort | facs analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms |
| work_keys_str_mv | AT romerob facsanalysisoftheplanarianstemcellcompartmentasatooltounderstandregenerativemechanisms AT evansd facsanalysisoftheplanarianstemcellcompartmentasatooltounderstandregenerativemechanisms AT aboobakera facsanalysisoftheplanarianstemcellcompartmentasatooltounderstandregenerativemechanisms |