Outcome measures in solid organ donor management research: a systematic review
Aim We systematically reviewed published outcome measures across randomised controlled trials (RCTs) of donor management interventions. Methods The systematic review was conducted in accordance with recommendations by the Cochrane Handbook and Preferred Reporting Items for Systematic Reviews and Met...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2021
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| _version_ | 1797107450882555904 |
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| author | Bera, KD Shah, A English, MR Ploeg, R |
| author_facet | Bera, KD Shah, A English, MR Ploeg, R |
| author_sort | Bera, KD |
| collection | OXFORD |
| description | Aim
We systematically reviewed published outcome measures across randomised controlled trials (RCTs) of donor management interventions.
Methods
The systematic review was conducted in accordance with recommendations by the Cochrane Handbook and Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. We searched MEDLINE, Embase, CENTRAL, Web of Science, and trial databases from 1980 to February 2021 for RCTs of donor management interventions.
Results
Twenty-two RCTs (n=3432 donors) were included in our analysis. Fourteen RCTs (63.6%) reported a primary outcome relating to a single organ only. Eight RCTs primarily focused on aspects of donor optimisation in critical care. Thyroid hormones and methylprednisolone were the most commonly evaluated interventions (five and four studies, respectively). Only two studies, focusing on single organs (e.g. kidney), evaluated outcomes relating to other organs. The majority of studies evaluated physiological or biomarker-related outcomes. No study evaluated recipient health-related quality of life. Only one study sought consent from potential organ recipients.
Conclusions
The majority of RCTs evaluating donor management interventions only assessed single-organ outcomes or effects on donor stability in critical care. There is a need for an evaluation of patient-centred recipient outcomes and standardisation and reporting of outcome measures for future donor management RCTs.
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| first_indexed | 2024-03-07T07:16:18Z |
| format | Journal article |
| id | oxford-uuid:12518802-d533-4963-a356-0ca21049fca6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:16:18Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:12518802-d533-4963-a356-0ca21049fca62022-08-19T07:38:40ZOutcome measures in solid organ donor management research: a systematic reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:12518802-d533-4963-a356-0ca21049fca6EnglishSymplectic ElementsElsevier2021Bera, KDShah, AEnglish, MRPloeg, RAim We systematically reviewed published outcome measures across randomised controlled trials (RCTs) of donor management interventions. Methods The systematic review was conducted in accordance with recommendations by the Cochrane Handbook and Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. We searched MEDLINE, Embase, CENTRAL, Web of Science, and trial databases from 1980 to February 2021 for RCTs of donor management interventions. Results Twenty-two RCTs (n=3432 donors) were included in our analysis. Fourteen RCTs (63.6%) reported a primary outcome relating to a single organ only. Eight RCTs primarily focused on aspects of donor optimisation in critical care. Thyroid hormones and methylprednisolone were the most commonly evaluated interventions (five and four studies, respectively). Only two studies, focusing on single organs (e.g. kidney), evaluated outcomes relating to other organs. The majority of studies evaluated physiological or biomarker-related outcomes. No study evaluated recipient health-related quality of life. Only one study sought consent from potential organ recipients. Conclusions The majority of RCTs evaluating donor management interventions only assessed single-organ outcomes or effects on donor stability in critical care. There is a need for an evaluation of patient-centred recipient outcomes and standardisation and reporting of outcome measures for future donor management RCTs. |
| spellingShingle | Bera, KD Shah, A English, MR Ploeg, R Outcome measures in solid organ donor management research: a systematic review |
| title | Outcome measures in solid organ donor management research: a systematic review |
| title_full | Outcome measures in solid organ donor management research: a systematic review |
| title_fullStr | Outcome measures in solid organ donor management research: a systematic review |
| title_full_unstemmed | Outcome measures in solid organ donor management research: a systematic review |
| title_short | Outcome measures in solid organ donor management research: a systematic review |
| title_sort | outcome measures in solid organ donor management research a systematic review |
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