The allelic landscape of human blood cell trait variation and links to common complex disease

The allelic landscape of human blood cell trait variation and links to common complex disease

Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL studies, testing 29.5 million genetic variants for association with 36 red cell,...

Bibliografski detalji
Glavni autori:	Astle, WJ, Elding, H, Jiang, T, Allen, D, Ruklisa, D, Mann, AL, Mead, D, Bouman, H, Riveros-Mckay, F, Kostadima, MA, Lambourne, JJ, Sivapalaratnam, S, Downes, K, Kundu, K, Bomba, L, Berentsen, K, Bradley, JR, Daugherty, LC, Delaneau, O, Freson, K, Garner, SF, Grassi, L, Guerrero, J, Haimel, M, Janssen-Megens, EM, Kaan, A, Kamat, M, Kim, B, Mandoli, A, Marchini, J, Martens, JH, Meacham, S, Megy, K, O'Connell, J, Petersen, R, Sharifi, N, Sheard, SM, Staley, JR, Tuna, S, van der Ent, M, Walter, K, Wang, SY, Wheeler, E, Wilder, SP, Iotchkova, V, Moore, C, Sambrook, J, Stunnenberg, HG, Di Angelantonio, E, Kaptoge, S, Kuijpers, TW, Carrillo-de-Santa-Pau, E, Juan, D, Rico, D, Valencia, A, Chen, L, Ge, B, Vasquez, L, Kwan, T, Garrido-Martín, D, Watt, S, Yang, Y, Guigo, R, Beck, S, Paul, DS, Pastinen, T, Bujold, D, Bourque, G, Frontini, M, Danesh, J, Roberts, DJ, Ouwehand, WH, Butterworth, AS, Soranzo, N
Format:	Journal article
Jezik:	English
Izdano:	Cell Press 2016

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