The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists

Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR-dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type-specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by th...

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Bibliographic Details
Main Authors: Chen, KW, Bezbradica, J, Groß, CJ, Wall, AA, Sweet, MJ, Stow, JL, Schroder, K
Format: Journal article
Language:English
Published: Wiley 2016