Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.

Naturally occurring CD4+ regulatory T cells (T(R)) that express CD25 and the transcription factor FoxP3 play a key role in immune homeostasis, preventing immune pathological responses to self and foreign Ags. CTLA-4 is expressed by a high percentage of these cells, and is often considered as a marke...

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Bibliographic Details
Main Authors:	Read, S, Greenwald, R, Izcue, A, Robinson, N, Mandelbrot, D, Francisco, L, Sharpe, A, Powrie, F
Format:	Journal article
Language:	English
Published:	2006

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