Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array.
Optical platforms for assaying membrane protein function offer a promising route to scalable high-throughput screening (see picture). For the first time quantitative measurements of membrane protein inhibition are reported in an optically addressable lipid bilayer array. Wide-field total internal re...
| Huvudupphovsmän: | , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2012
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| Sammanfattning: | Optical platforms for assaying membrane protein function offer a promising route to scalable high-throughput screening (see picture). For the first time quantitative measurements of membrane protein inhibition are reported in an optically addressable lipid bilayer array. Wide-field total internal reflection fluorescence (TIRF) imaging of Ca 2+ flux enables the quantification of α-hemolysin inhibition by γ-cyclodextrin. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
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