Revisiting the point-source hypothesis of the coronary heart disease epidemic in light of the COVID-19 pandemic

The 20th century coronary heart disease pandemic remains a partial enigma. Here we focus on sex differences in mortality as an indicator of the disease during a time when classification of cause of death was uncertain. We suggest that cohorts born during a few decades around the turn of the century...

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Bibliographic Details
Main Authors: Davey Smith, G, Dorling, D
Format: Conference item
Language:English
Published: Society for Epidemiologic Research 2023
Description
Summary:The 20th century coronary heart disease pandemic remains a partial enigma. Here we focus on sex differences in mortality as an indicator of the disease during a time when classification of cause of death was uncertain. We suggest that cohorts born during a few decades around the turn of the century bore the brunt of the pandemic, and propose that the 1889-1895 Russian influenza epidemic may have contributed to this. That some evidence points to the introduction of a human seasonal coronavirus during the 1889-95 pandemic adds contemporary relevance to these speculations.