In vivo and in vitro activities and ADME-Tox profile of a quinolizidine-modified 4-aminoquinoline: A potent Anti-P. falciparum and anti-P. vivax blood-stage antimalarial

In vivo and in vitro activities and ADME-Tox profile of a quinolizidine-modified 4-aminoquinoline: A potent Anti-P. falciparum and anti-P. vivax blood-stage antimalarial

Natural products are a prolific source for the identification of new biologically active compounds. In the present work, we studied the in vitro and in vivo antimalarial efficacy and ADME-Tox profile of a molecular hybrid (AM1) between 4-aminoquinoline and a quinolizidine moiety derived from lupinin...

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Bibliographic Details
Main Authors: Basilico, N, Parapini, S, Sparatore, A, Romeo, S, Misiano, P, Vivas, L, Yardley, V, Croft, S, Habluetzel, A, Lucantoni, L, Renia, L, Russell, B, Suwanarusk, R, Nosten, F, Dondio, G, Bigogno, C, Jabes, D, Taramelli, D
Format: Journal article
Language:English
Published: MDPI 2017

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