Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2019
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| _version_ | 1826259983859187712 |
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| author | Bentley, AR Sung, YJ Brown, MR Goel, A Morris, AP Farrall, M Watkins, H Franks, PW van Duijn, CM |
| author_facet | Bentley, AR Sung, YJ Brown, MR Goel, A Morris, AP Farrall, M Watkins, H Franks, PW van Duijn, CM |
| author_sort | Bentley, AR |
| collection | OXFORD |
| description | The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. |
| first_indexed | 2024-03-06T18:58:27Z |
| format | Journal article |
| id | oxford-uuid:12b0d5c7-efc9-4644-875b-44f090c44e27 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:58:27Z |
| publishDate | 2019 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:12b0d5c7-efc9-4644-875b-44f090c44e272022-03-26T10:09:20ZMulti-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipidsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:12b0d5c7-efc9-4644-875b-44f090c44e27EnglishSymplectic Elements at OxfordSpringer Nature2019Bentley, ARSung, YJBrown, MRGoel, AMorris, APFarrall, MWatkins, HFranks, PWvan Duijn, CMThe concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. |
| spellingShingle | Bentley, AR Sung, YJ Brown, MR Goel, A Morris, AP Farrall, M Watkins, H Franks, PW van Duijn, CM Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids |
| title | Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids |
| title_full | Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids |
| title_fullStr | Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids |
| title_full_unstemmed | Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids |
| title_short | Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids |
| title_sort | multi ancestry genome wide gene smoking interaction study of 387 272 individuals identifies new loci associated with serum lipids |
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