In vivo monitoring of intranuclear p27(kip1) protein expression in breast cancer cells during trastuzumab (Herceptin) therapy.

INTRODUCTION: Trastuzumab, a humanized antibody directed against the Her2 receptor, induces the expression of p27(kip1), an intranuclear cyclin-dependent kinase inhibitor in some breast cancer cells. The aim of this study was to develop a radioimmunoconjugate (RIC) to monitor trastuzumab-induced p27...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Cornelissen, B, Kersemans, V, McLarty, K, Tran, L, Vallis, K, Reilly, R
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: 2009