In vivo monitoring of intranuclear p27(kip1) protein expression in breast cancer cells during trastuzumab (Herceptin) therapy.

INTRODUCTION: Trastuzumab, a humanized antibody directed against the Her2 receptor, induces the expression of p27(kip1), an intranuclear cyclin-dependent kinase inhibitor in some breast cancer cells. The aim of this study was to develop a radioimmunoconjugate (RIC) to monitor trastuzumab-induced p27...

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Autori principali: Cornelissen, B, Kersemans, V, McLarty, K, Tran, L, Vallis, K, Reilly, R
Natura: Journal article
Lingua:English
Pubblicazione: 2009