Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research
Dendrons are an important class of macromolecules that can be used for a broad range of applications. Recent studies indicated that mixtures of oligoglycerol detergent (OGD) regioisomers are superior over individual regioisomers for protein extraction. The origin of this phenomenon remains puzzling....
| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Wiley
2020
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| _version_ | 1826260028319858688 |
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| author | Urner, LH Goltsche, K Selent, M Liko, I Schweder, M-P Robinson, CV Pagel, K Haag, R |
| author_facet | Urner, LH Goltsche, K Selent, M Liko, I Schweder, M-P Robinson, CV Pagel, K Haag, R |
| author_sort | Urner, LH |
| collection | OXFORD |
| description | Dendrons are an important class of macromolecules that can be used for a broad range of applications. Recent studies indicated that mixtures of oligoglycerol detergent (OGD) regioisomers are superior over individual regioisomers for protein extraction. The origin of this phenomenon remains puzzling. Here we discuss the synthesis and characterization of dendritic oligoglycerol regioisomer mixtures and their implementation into detergents. We provide experimental benchmarks to support quality control after synthesis and investigate the unusual utility of OGD regioisomer mixtures for extracting large protein quantities from biological membranes. We anticipate that our findings will enable the development of mixed detergent platforms in the future. |
| first_indexed | 2024-03-06T18:59:07Z |
| format | Journal article |
| id | oxford-uuid:12e98dc9-4777-4967-b08f-1c8aa37d996c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:59:07Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:12e98dc9-4777-4967-b08f-1c8aa37d996c2022-03-26T10:10:46ZDendritic oligoglycerol regioisomer mixtures and their utility for membrane protein researchJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:12e98dc9-4777-4967-b08f-1c8aa37d996cEnglishSymplectic ElementsWiley2020Urner, LHGoltsche, KSelent, MLiko, ISchweder, M-PRobinson, CVPagel, KHaag, RDendrons are an important class of macromolecules that can be used for a broad range of applications. Recent studies indicated that mixtures of oligoglycerol detergent (OGD) regioisomers are superior over individual regioisomers for protein extraction. The origin of this phenomenon remains puzzling. Here we discuss the synthesis and characterization of dendritic oligoglycerol regioisomer mixtures and their implementation into detergents. We provide experimental benchmarks to support quality control after synthesis and investigate the unusual utility of OGD regioisomer mixtures for extracting large protein quantities from biological membranes. We anticipate that our findings will enable the development of mixed detergent platforms in the future. |
| spellingShingle | Urner, LH Goltsche, K Selent, M Liko, I Schweder, M-P Robinson, CV Pagel, K Haag, R Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research |
| title | Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research |
| title_full | Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research |
| title_fullStr | Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research |
| title_full_unstemmed | Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research |
| title_short | Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research |
| title_sort | dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research |
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