Calculation of carcinogenic potency from long-term animal carcinogenesis experiments.
An index of carcinogenic potency for chemicals tested in chronic animal experiments is described. By analogy with the well-known 'lethal dose 50' (LD50) of quantal bioassay, a 'tumorigenic dose 50' (TD50) may be defined (in the absence both of tumors in the control group and of i...
| Hlavní autoři: | , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
1984
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| _version_ | 1826260038059032576 |
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| author | Sawyer, C Peto, R Bernstein, L Pike, M |
| author_facet | Sawyer, C Peto, R Bernstein, L Pike, M |
| author_sort | Sawyer, C |
| collection | OXFORD |
| description | An index of carcinogenic potency for chemicals tested in chronic animal experiments is described. By analogy with the well-known 'lethal dose 50' (LD50) of quantal bioassay, a 'tumorigenic dose 50' (TD50) may be defined (in the absence both of tumors in the control group and of intercurrent deaths) as that (daily) dose of chemical which gives 50% of the test animals tumors by some fixed age. Tumors in the control (zero-dose) group are handled exactly as for the LD50, and intercurrent deaths are handled by life-table methods. Nonparametric procedures are developed for estimating the TD50 and for constructing confidence intervals. These are based on likelihoods which assume that the tumor hazard is linear in dose. |
| first_indexed | 2024-03-06T18:59:16Z |
| format | Journal article |
| id | oxford-uuid:12f492e1-f94a-439b-b4b1-c5a8bf4c9f93 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:59:16Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:12f492e1-f94a-439b-b4b1-c5a8bf4c9f932022-03-26T10:11:02ZCalculation of carcinogenic potency from long-term animal carcinogenesis experiments.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:12f492e1-f94a-439b-b4b1-c5a8bf4c9f93EnglishSymplectic Elements at Oxford1984Sawyer, CPeto, RBernstein, LPike, MAn index of carcinogenic potency for chemicals tested in chronic animal experiments is described. By analogy with the well-known 'lethal dose 50' (LD50) of quantal bioassay, a 'tumorigenic dose 50' (TD50) may be defined (in the absence both of tumors in the control group and of intercurrent deaths) as that (daily) dose of chemical which gives 50% of the test animals tumors by some fixed age. Tumors in the control (zero-dose) group are handled exactly as for the LD50, and intercurrent deaths are handled by life-table methods. Nonparametric procedures are developed for estimating the TD50 and for constructing confidence intervals. These are based on likelihoods which assume that the tumor hazard is linear in dose. |
| spellingShingle | Sawyer, C Peto, R Bernstein, L Pike, M Calculation of carcinogenic potency from long-term animal carcinogenesis experiments. |
| title | Calculation of carcinogenic potency from long-term animal carcinogenesis experiments. |
| title_full | Calculation of carcinogenic potency from long-term animal carcinogenesis experiments. |
| title_fullStr | Calculation of carcinogenic potency from long-term animal carcinogenesis experiments. |
| title_full_unstemmed | Calculation of carcinogenic potency from long-term animal carcinogenesis experiments. |
| title_short | Calculation of carcinogenic potency from long-term animal carcinogenesis experiments. |
| title_sort | calculation of carcinogenic potency from long term animal carcinogenesis experiments |
| work_keys_str_mv | AT sawyerc calculationofcarcinogenicpotencyfromlongtermanimalcarcinogenesisexperiments AT petor calculationofcarcinogenicpotencyfromlongtermanimalcarcinogenesisexperiments AT bernsteinl calculationofcarcinogenicpotencyfromlongtermanimalcarcinogenesisexperiments AT pikem calculationofcarcinogenicpotencyfromlongtermanimalcarcinogenesisexperiments |