Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy

Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy

Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across C. difficile underscores its wide ecological versatility and has driven the significant changes in CDI epidemiology seen in the last 20 years. We analysed an international colle...

Full description

Bibliographic Details
Main Authors:	Knight, DR, Imwattana, K, Kullin, B, Guerrero-Araya, E, Paredes-Sabja, D, Didelot, X, Dingle, KE, Eyre, DW, Rodríguez, C, Riley, TV
Format:	Journal article
Language:	English
Published:	eLife Sciences Publications 2021

Similar Items

Possible contribution of shoes to clostridioides difficile transmission within hospitals
by: Janezic, S, et al.
Published: (2020)

Penicillin binding protein substitutions co-occur with fluoroquinolone resistance in ‘epidemic’ lineages of multi drug-resistant Clostridioides difficile
by: Dingle, K, et al.
Published: (2023)

In vitro activity of eravacycline against common ribotypes of Clostridioides difficile
by: Bassères, E, et al.
Published: (2020)

K-mer based prediction of Clostridioides difficile relatedness and ribotypes
by: Moore, M, et al.
Published: (2022)

Gut metabolites predict Clostridioides difficile recurrence
by: Dawkins, Jennifer J., et al.
Published: (2022)

Membrane vesicles of clostridioides difficile and other clostridial species
by: Goh, Shan, et al.
Published: (2024)

In vitro activity of omadacycline, a new tetracycline analog, and comparators against Clostridioides difficile.
by: Begum, K, et al.
Published: (2020)

High Prevalence of Toxigenic and Nontoxigenic Clostridium difficile Strains in Malaysia
by: Riley, Thomas V., et al.
Published: (2018)

Trends in incidence and clinical outcomes of Clostridioides difficile infection, Hong Kong
by: Guo, Cosmos L. T., et al.
Published: (2022)

Risk factors and treatment outcomes of severe Clostridioides difficile infection in Singapore
by: Tay, Hui Lin, et al.
Published: (2020)

Contribution to Clostridium difficile transmission of symptomatic patients with toxigenic strains who are fecal toxin negative
by: Mawer, D, et al.
Published: (2017)

WGS to determine the extent of Clostridioides difficile transmission in a high incidence setting in North Wales in 2015
by: Eyre, D, et al.
Published: (2018)

The Complexity and Diversity of the Pathogenicity Locus in Clostridium difficile Clade 5.
by: Elliott, B, et al.
Published: (2014)

The clinical and environmental spread and diversity of toxigenic Clostridium difficile diarrhea in the region of the Middle East.
by: N., Sadeghifard, et al.
Published: (2010)

Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms
by: Kester, Jemila C., et al.
Published: (2020)

Probabilistic transmission models incorporating sequencing data for healthcare-associated Clostridioides difficile outperform heuristic rules and identify strain-specific differences in transmission
by: Eyre, D, et al.
Published: (2021)

Efficacy of Dry Heat Treatment against Clostridioides difficile Spores and Mycobacterium tuberculosis on Filtering Facepiece Respirators
by: Soni, A, et al.
Published: (2022)

Evolutionary history of the Clostridium difficile pathogenicity locus.
by: Dingle, K, et al.
Published: (2014)

Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification
by: Chan, Hung, et al.
Published: (2022)

Clostridium difficile in England: can we stop washing our hands? - Authors' reply.
by: Eyre, D, et al.
Published: (2017)

Clostridium difficile mixed infection and reinfection.
by: Eyre, D, et al.
Published: (2012)

Quantitative study of Clostridium difficile transmission using extensive epidemiological data and whole genome sequencing
by: Eyre, DW
Published: (2013)

Hash-based core genome multilocus sequencing typing for Clostridium difficile
by: Eyre, DW, et al.
Published: (2019)

Clostridium difficile trehalose metabolism variants are common and not associated with adverse patient outcomes when variably present in the same lineage
by: Eyre, D, et al.
Published: (2019)

Microevolutionary analysis of Clostridium difficile genomes to investigate transmission.
by: Didelot, X, et al.
Published: (2012)

Microevolutionary analysis of Clostridium difficile genomes to investigate transmission
by: Didelot, X, et al.
Published: (2012)

Comparison of alcohol shock enrichment and selective enrichment for the isolation of Clostridium difficile
by: Riley, T.V., et al.
Published: (1987)

Clinical Clostridium difficile: clonality and pathogenicity locus diversity.
by: Dingle, K, et al.
Published: (2011)

Epidemiology of Clostridium difficile in infants in Oxfordshire, UK: risk factors for colonization and carriage, and genetic overlap with regional C. difficile infection strains
by: Stoesser, N, et al.
Published: (2017)

Evaluation of the detection techniques of toxigenic Aspergillus isolates
by: Darab, Yazdani, et al.
Published: (2010)

Diverse sources of C. difficile infection identified on whole-genome sequencing.
by: Eyre, D, et al.
Published: (2013)

Diverse sources of C. difficile infection identified on whole-genome sequencing
by: Eyre, D, et al.
Published: (2013)

Predictors of first recurrence of Clostridium difficile infection: implications for initial management.
by: Eyre, D, et al.
Published: (2012)

Molecular epidemiology of Clostridium difficile strains in children compared with that of strains circulating in adults with Clostridium difficile-associated infection.
by: Stoesser, N, et al.
Published: (2011)

A role for tetracycline selection in recent evolution of agriculture-associated Clostridium difficile PCR ribotype 078
by: Dingle, K, et al.
Published: (2019)

Clostridium difficile surveillance: harnessing new technologies to control transmission.
by: Eyre, D, et al.
Published: (2013)

Effects of control interventions on Clostridium difficile infection in England: an observational study
by: Dingle, K, et al.
Published: (2017)

Multilocus sequence typing of Clostridium difficile.
by: Griffiths, D, et al.
Published: (2010)

Toxigenic Campylobacter jejuni in vegetables farms and retail outlets in Terengganu
by: Tang, John Yew Huat, et al.
Published: (2017)

Molecular epidemiology of Clostridium difficile isolated from piglets
by: Putsathit, Papanin, et al.
Published: (2019)