Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis
Although most children with cerebral malaria fully recover, more than a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating neurological dysfunction in cerebral malaria are still debata...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer
2024
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| _version_ | 1824458961825300480 |
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| author | Kioko, M Mwangi, S Njunge, JM Berkley, JA Bejon, P Abdi, AI |
| author_facet | Kioko, M Mwangi, S Njunge, JM Berkley, JA Bejon, P Abdi, AI |
| author_sort | Kioko, M |
| collection | OXFORD |
| description | Although most children with cerebral malaria fully recover, more than a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating neurological dysfunction in cerebral malaria are still debatable. In this article, we explore available data and hypothesise that cerebral malaria might be linked to APOE-mediated amyloidosis, one of the pathological processes associated with Alzheimer’s disease. If our hypothesis is tested and found to be true, it could have far-reaching implications for what we know about cerebral malaria pathogenesis. |
| first_indexed | 2025-02-19T04:34:13Z |
| format | Journal article |
| id | oxford-uuid:1304ff69-8b5b-4b9c-919c-bdd86d01b375 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:34:13Z |
| publishDate | 2024 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:1304ff69-8b5b-4b9c-919c-bdd86d01b3752025-01-27T20:06:46ZLinking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and HypothesisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1304ff69-8b5b-4b9c-919c-bdd86d01b375EnglishJisc Publications RouterSpringer2024Kioko, MMwangi, SNjunge, JMBerkley, JABejon, PAbdi, AIAlthough most children with cerebral malaria fully recover, more than a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating neurological dysfunction in cerebral malaria are still debatable. In this article, we explore available data and hypothesise that cerebral malaria might be linked to APOE-mediated amyloidosis, one of the pathological processes associated with Alzheimer’s disease. If our hypothesis is tested and found to be true, it could have far-reaching implications for what we know about cerebral malaria pathogenesis. |
| spellingShingle | Kioko, M Mwangi, S Njunge, JM Berkley, JA Bejon, P Abdi, AI Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis |
| title | Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis |
| title_full | Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis |
| title_fullStr | Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis |
| title_full_unstemmed | Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis |
| title_short | Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis |
| title_sort | linking cerebral malaria pathogenesis to apoe mediated amyloidosis observations and hypothesis |
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