Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more...

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Main Authors: Ellinghaus, D, Jostins, L, Spain, S, Cortes, A, Bethune, J, Han, B, Park, Y, Raychaudhuri, S, Pouget, J, Hübenthal, M, Folseraas, T, Wang, Y, Esko, T, Metspalu, A, Westra, H, Franke, L, Pers, T, Weersma, R, Collij, V, D'Amato, M, Halfvarson, J, Jensen, A, Lieb, W, Degenhardt, F, Forstner, A, Hofmann, A, Schreiber, S, Mrowietz, U, Juran, B, Lazaridis, K, Brunak, S, Dale, A, Trembath, R, Weidinger, S, Weichenthal, M, Ellinghaus, E, Elder, J, Barker, J, Andreassen, O, McGovern, D, Karlsen, T, Barrett, J, Parkes, M, Brown, M, Franke, A
Format: Journal article
Language:English
Published: Nature 2016

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