PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation

PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation

Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for chromatin regulation by long non-coding RNAs. Here we show that the non-canonical PCGF3/5-PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to Xist RNA expression. PCGF3/5-PRC1...

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Bibliographic Details
Main Authors:	Almeida, M, Pintacuda, G, Masui, O, Koseki, Y, Gdula, M, Cerase, A, Brown, D, Mould, A, Innocent, C, Nakayama, M, Schermelleh, L, Nesterova, T, Koseki, H, Brockdorff, N
Format:	Journal article
Language:	English
Published:	American Association for the Advancement of Science 2017

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