Dreaming with hippocampal damage
The hippocampus is linked with both sleep and memory, but there is debate about whether a salient aspect of sleep – dreaming – requires its input. To address this question, we investigated if human patients with focal bilateral hippocampal damage and amnesia engaged in dreaming. We employed a provok...
| Main Authors: | , , , , , , , , |
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| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
eLife Sciences Publications, Ltd
2020
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| _version_ | 1826260080484417536 |
|---|---|
| author | Spanò, G Pizzamiglio, G McCormick, C Clark, IA De Felice, S Miller, TD Edgin, JO Rosenthal, CR Maguire, EA |
| author_facet | Spanò, G Pizzamiglio, G McCormick, C Clark, IA De Felice, S Miller, TD Edgin, JO Rosenthal, CR Maguire, EA |
| author_sort | Spanò, G |
| collection | OXFORD |
| description | The hippocampus is linked with both sleep and memory, but there is debate about
whether a salient aspect of sleep – dreaming – requires its input. To address this question, we
investigated if human patients with focal bilateral hippocampal damage and amnesia engaged in
dreaming. We employed a provoked awakening protocol where participants were woken up at
various points throughout the night, including during non-rapid eye movement and rapid eye
movement sleep, to report their thoughts in that moment. Despite being roused a similar number
of times, dream frequency was reduced in the patients compared to control participants, and the
few dreams they reported were less episodic-like in nature and lacked content. These results
suggest that hippocampal integrity may be necessary for typical dreaming to occur, and aligns
dreaming with other hippocampal-dependent processes such as episodic memory that are central
to supporting our mental life. |
| first_indexed | 2024-03-06T18:59:57Z |
| format | Journal article |
| id | oxford-uuid:1330ebce-9081-4cb6-a73b-cd6bc232bd72 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:59:57Z |
| publishDate | 2020 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | dspace |
| spelling | oxford-uuid:1330ebce-9081-4cb6-a73b-cd6bc232bd722022-03-26T10:12:24ZDreaming with hippocampal damageJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1330ebce-9081-4cb6-a73b-cd6bc232bd72EnglishSymplectic ElementseLife Sciences Publications, Ltd2020Spanò, GPizzamiglio, GMcCormick, CClark, IADe Felice, SMiller, TDEdgin, JORosenthal, CRMaguire, EAThe hippocampus is linked with both sleep and memory, but there is debate about whether a salient aspect of sleep – dreaming – requires its input. To address this question, we investigated if human patients with focal bilateral hippocampal damage and amnesia engaged in dreaming. We employed a provoked awakening protocol where participants were woken up at various points throughout the night, including during non-rapid eye movement and rapid eye movement sleep, to report their thoughts in that moment. Despite being roused a similar number of times, dream frequency was reduced in the patients compared to control participants, and the few dreams they reported were less episodic-like in nature and lacked content. These results suggest that hippocampal integrity may be necessary for typical dreaming to occur, and aligns dreaming with other hippocampal-dependent processes such as episodic memory that are central to supporting our mental life. |
| spellingShingle | Spanò, G Pizzamiglio, G McCormick, C Clark, IA De Felice, S Miller, TD Edgin, JO Rosenthal, CR Maguire, EA Dreaming with hippocampal damage |
| title | Dreaming with hippocampal damage |
| title_full | Dreaming with hippocampal damage |
| title_fullStr | Dreaming with hippocampal damage |
| title_full_unstemmed | Dreaming with hippocampal damage |
| title_short | Dreaming with hippocampal damage |
| title_sort | dreaming with hippocampal damage |
| work_keys_str_mv | AT spanog dreamingwithhippocampaldamage AT pizzamigliog dreamingwithhippocampaldamage AT mccormickc dreamingwithhippocampaldamage AT clarkia dreamingwithhippocampaldamage AT defelices dreamingwithhippocampaldamage AT millertd dreamingwithhippocampaldamage AT edginjo dreamingwithhippocampaldamage AT rosenthalcr dreamingwithhippocampaldamage AT maguireea dreamingwithhippocampaldamage |