High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation

High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation

This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals within 10 weeks of ch...

Full description

Bibliographic Details
Main Authors: Sibley, L, White, AD, Gooch, KE, Stevens, LM, Tanner, R, Jacobs, A, Daykin-Pont, O, Gleeson, F, McIntyre, A, Basaraba, R, Clark, S, Hall, G, Pearson, G, Rayner, E, McShane, H, Williams, A, Dennis, M, Marsh, PD, Sharpe, S
Format: Journal article
Language:English
Published: Springer Nature 2021

Similar Items

Similar Items