The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis.
Influenza virus immune human T-lymphocyte clones maintained in continuous culture in TCGF were analysed for helper activity and interleukin-2 (IL-2) production. The clones that functioned as helper cells in the production of specific antibody failed to release detectable amounts of IL-2. Conversely,...
| Hlavní autoři: | , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
1983
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| _version_ | 1826260133922996224 |
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| author | Lamb, JR Zanders, E Feldmann, M Lake, P Eckels, D Woody, J Beverley, P |
| author_facet | Lamb, JR Zanders, E Feldmann, M Lake, P Eckels, D Woody, J Beverley, P |
| author_sort | Lamb, JR |
| collection | OXFORD |
| description | Influenza virus immune human T-lymphocyte clones maintained in continuous culture in TCGF were analysed for helper activity and interleukin-2 (IL-2) production. The clones that functioned as helper cells in the production of specific antibody failed to release detectable amounts of IL-2. Conversely, the T cells that produced IL-2 were unable to provide either specific or non-specific helper function. These findings indicated the IL-2 is not an essential component for helper activity. However, phenotypic analysis revealed that both the functional subsets of T-cell clones expressed the helper phenotype in that they were T4+, T3+ and T11+. Nevertheless analysis with other antibodies revealed differences in that the IL-2 releasing clone showed greater staining with the anti-T-cell subset antibodies 9.3 and Leu 8, confirming that there is phenotype as well as functional heterogeneity within the helper inducer T-cell population. |
| first_indexed | 2024-03-06T19:00:49Z |
| format | Journal article |
| id | oxford-uuid:13752f10-8173-47c0-987e-c2a6587ed04c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:00:49Z |
| publishDate | 1983 |
| record_format | dspace |
| spelling | oxford-uuid:13752f10-8173-47c0-987e-c2a6587ed04c2022-03-26T10:14:01ZThe dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:13752f10-8173-47c0-987e-c2a6587ed04cEnglishSymplectic Elements at Oxford1983Lamb, JRZanders, EFeldmann, MLake, PEckels, DWoody, JBeverley, PInfluenza virus immune human T-lymphocyte clones maintained in continuous culture in TCGF were analysed for helper activity and interleukin-2 (IL-2) production. The clones that functioned as helper cells in the production of specific antibody failed to release detectable amounts of IL-2. Conversely, the T cells that produced IL-2 were unable to provide either specific or non-specific helper function. These findings indicated the IL-2 is not an essential component for helper activity. However, phenotypic analysis revealed that both the functional subsets of T-cell clones expressed the helper phenotype in that they were T4+, T3+ and T11+. Nevertheless analysis with other antibodies revealed differences in that the IL-2 releasing clone showed greater staining with the anti-T-cell subset antibodies 9.3 and Leu 8, confirming that there is phenotype as well as functional heterogeneity within the helper inducer T-cell population. |
| spellingShingle | Lamb, JR Zanders, E Feldmann, M Lake, P Eckels, D Woody, J Beverley, P The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis. |
| title | The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis. |
| title_full | The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis. |
| title_fullStr | The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis. |
| title_full_unstemmed | The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis. |
| title_short | The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis. |
| title_sort | dissociation of interleukin 2 production and antigen specific helper activity by clonal analysis |
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