Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus.
Diabetes mellitus is associated with disturbed regulation in the microcirculation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that cyclooxy...
| Автори: | , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
2006
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| _version_ | 1826260167927267328 |
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| author | Bagi, Z Erdei, N Papp, Z Edes, I Koller, A |
| author_facet | Bagi, Z Erdei, N Papp, Z Edes, I Koller, A |
| author_sort | Bagi, Z |
| collection | OXFORD |
| description | Diabetes mellitus is associated with disturbed regulation in the microcirculation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that cyclooxygenase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids, via up-regulation of COX-2, interferes with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular tone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus. |
| first_indexed | 2024-03-06T19:01:21Z |
| format | Journal article |
| id | oxford-uuid:13a1673f-76ce-4be7-83db-a2ced74a24db |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:01:21Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:13a1673f-76ce-4be7-83db-a2ced74a24db2022-03-26T10:15:01ZUp-regulation of vascular cyclooxygenase-2 in diabetes mellitus.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:13a1673f-76ce-4be7-83db-a2ced74a24dbEnglishSymplectic Elements at Oxford2006Bagi, ZErdei, NPapp, ZEdes, IKoller, ADiabetes mellitus is associated with disturbed regulation in the microcirculation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that cyclooxygenase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids, via up-regulation of COX-2, interferes with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular tone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus. |
| spellingShingle | Bagi, Z Erdei, N Papp, Z Edes, I Koller, A Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. |
| title | Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. |
| title_full | Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. |
| title_fullStr | Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. |
| title_full_unstemmed | Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. |
| title_short | Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. |
| title_sort | up regulation of vascular cyclooxygenase 2 in diabetes mellitus |
| work_keys_str_mv | AT bagiz upregulationofvascularcyclooxygenase2indiabetesmellitus AT erdein upregulationofvascularcyclooxygenase2indiabetesmellitus AT pappz upregulationofvascularcyclooxygenase2indiabetesmellitus AT edesi upregulationofvascularcyclooxygenase2indiabetesmellitus AT kollera upregulationofvascularcyclooxygenase2indiabetesmellitus |