Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation.
During antigen recognition by T cells different receptors and ligands form a pattern in the intercellular junction called the immunological synapse, which might be involved in T-cell activation. Recently, a synapse assembly model has been proposed, which enables the calculation of the propensity for...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1797054737222205440 |
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| author | Lee, S Hori, Y Groves, J Dustin, M Chakraborty, A |
| author_facet | Lee, S Hori, Y Groves, J Dustin, M Chakraborty, A |
| author_sort | Lee, S |
| collection | OXFORD |
| description | During antigen recognition by T cells different receptors and ligands form a pattern in the intercellular junction called the immunological synapse, which might be involved in T-cell activation. Recently, a synapse assembly model has been proposed, which enables the calculation of the propensity for synapse assembly driven by membrane-constrained protein binding interactions. We bring together model predictions of mature synapse assembly with data on the dependence of T-cell responses on T-cell receptor (TCR)-MHC-peptide (pMHC) binding kinetics. Predictions of mature synapse assembly, based on TCR-pMHC binding kinetics, correlate well with observed cytokine responses by T cells bearing the relevant TCR but not with cytotoxic T lymphocyte-mediated killing. We discuss the suggested different role for the synapse in pre- and post-nuclear activation events in T cells. The view of immunological synapse assembly given here emphasizes the importance of both the on and off rates for the TCR-pMHC interaction and in this context recent data on a positive role for analogs of self-peptides in synapse assembly is considered. |
| first_indexed | 2024-03-06T19:01:26Z |
| format | Journal article |
| id | oxford-uuid:13a927a5-5cf1-43a7-8f40-9dab4ba82ab8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:01:26Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:13a927a5-5cf1-43a7-8f40-9dab4ba82ab82022-03-26T10:15:06ZCorrelation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:13a927a5-5cf1-43a7-8f40-9dab4ba82ab8EnglishSymplectic Elements at Oxford2002Lee, SHori, YGroves, JDustin, MChakraborty, ADuring antigen recognition by T cells different receptors and ligands form a pattern in the intercellular junction called the immunological synapse, which might be involved in T-cell activation. Recently, a synapse assembly model has been proposed, which enables the calculation of the propensity for synapse assembly driven by membrane-constrained protein binding interactions. We bring together model predictions of mature synapse assembly with data on the dependence of T-cell responses on T-cell receptor (TCR)-MHC-peptide (pMHC) binding kinetics. Predictions of mature synapse assembly, based on TCR-pMHC binding kinetics, correlate well with observed cytokine responses by T cells bearing the relevant TCR but not with cytotoxic T lymphocyte-mediated killing. We discuss the suggested different role for the synapse in pre- and post-nuclear activation events in T cells. The view of immunological synapse assembly given here emphasizes the importance of both the on and off rates for the TCR-pMHC interaction and in this context recent data on a positive role for analogs of self-peptides in synapse assembly is considered. |
| spellingShingle | Lee, S Hori, Y Groves, J Dustin, M Chakraborty, A Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. |
| title | Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. |
| title_full | Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. |
| title_fullStr | Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. |
| title_full_unstemmed | Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. |
| title_short | Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. |
| title_sort | correlation of a dynamic model for immunological synapse formation with effector functions two pathways to synapse formation |
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