Defence heterogeneity in host populations gives rise to pathogen diversity
Host organisms can harbour microbial symbionts that defend them from pathogen infection in addition to the resistance encoded by the host genome. Here, we investigated how variation in defences, generated from host genetic background and symbiont presence, affects the emergence of pathogen genetic d...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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University of Chicago Press
2024
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| _version_ | 1811139785188704256 |
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| author | Hoang, K Read, T King, K |
| author_facet | Hoang, K Read, T King, K |
| author_sort | Hoang, K |
| collection | OXFORD |
| description | Host organisms can harbour microbial symbionts that defend them from pathogen infection in addition to the resistance encoded by the host genome. Here, we investigated how variation in defences, generated from host genetic background and symbiont presence, affects the emergence of pathogen genetic diversity across evolutionary time. We passaged the opportunistic pathogen, Pseudomonas aeruginosa, through populations of the nematode Caenorhabditis elegans varying in genetic-based defences and prevalence of a protective symbiont. After 14 passages, we assessed the amount of genetic variation accumulated in evolved pathogen lineages. We found that diversity begets diversity. An overall greater level of pathogen whole genome and per gene genetic diversity was measured in pathogens evolved in mixed host populations compared to those evolved in host populations comprised of one type of defence. Our findings directly demonstrate that symbiont-generated heterogeneity in host defence can be a significant contributor to pathogen genetic variation. |
| first_indexed | 2024-03-07T08:28:40Z |
| format | Journal article |
| id | oxford-uuid:13ae283b-2b2b-4e8b-ba64-445412d67adc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:11:36Z |
| publishDate | 2024 |
| publisher | University of Chicago Press |
| record_format | dspace |
| spelling | oxford-uuid:13ae283b-2b2b-4e8b-ba64-445412d67adc2024-06-26T08:42:34ZDefence heterogeneity in host populations gives rise to pathogen diversityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:13ae283b-2b2b-4e8b-ba64-445412d67adcEnglishSymplectic ElementsUniversity of Chicago Press2024Hoang, KRead, TKing, KHost organisms can harbour microbial symbionts that defend them from pathogen infection in addition to the resistance encoded by the host genome. Here, we investigated how variation in defences, generated from host genetic background and symbiont presence, affects the emergence of pathogen genetic diversity across evolutionary time. We passaged the opportunistic pathogen, Pseudomonas aeruginosa, through populations of the nematode Caenorhabditis elegans varying in genetic-based defences and prevalence of a protective symbiont. After 14 passages, we assessed the amount of genetic variation accumulated in evolved pathogen lineages. We found that diversity begets diversity. An overall greater level of pathogen whole genome and per gene genetic diversity was measured in pathogens evolved in mixed host populations compared to those evolved in host populations comprised of one type of defence. Our findings directly demonstrate that symbiont-generated heterogeneity in host defence can be a significant contributor to pathogen genetic variation. |
| spellingShingle | Hoang, K Read, T King, K Defence heterogeneity in host populations gives rise to pathogen diversity |
| title | Defence heterogeneity in host populations gives rise to pathogen diversity |
| title_full | Defence heterogeneity in host populations gives rise to pathogen diversity |
| title_fullStr | Defence heterogeneity in host populations gives rise to pathogen diversity |
| title_full_unstemmed | Defence heterogeneity in host populations gives rise to pathogen diversity |
| title_short | Defence heterogeneity in host populations gives rise to pathogen diversity |
| title_sort | defence heterogeneity in host populations gives rise to pathogen diversity |
| work_keys_str_mv | AT hoangk defenceheterogeneityinhostpopulationsgivesrisetopathogendiversity AT readt defenceheterogeneityinhostpopulationsgivesrisetopathogendiversity AT kingk defenceheterogeneityinhostpopulationsgivesrisetopathogendiversity |