Gene expression profiling in the myelodysplastic syndromes.

The myelodysplastic syndromes (MDS) are a heterogeneous group of haematopoietic malignancies, characterized by blood cytopenias, ineffective hematopoiesis and hypercellular bone marrow. Several genetic alterations have been reported in MDS but these are not MDS-specific and the underlying molecular...

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Main Authors: Pellagatti, A, Fidler, C, Wainscoat, J, Boultwood, J
Format: Journal article
Language:English
Published: 2005
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author Pellagatti, A
Fidler, C
Wainscoat, J
Boultwood, J
author_facet Pellagatti, A
Fidler, C
Wainscoat, J
Boultwood, J
author_sort Pellagatti, A
collection OXFORD
description The myelodysplastic syndromes (MDS) are a heterogeneous group of haematopoietic malignancies, characterized by blood cytopenias, ineffective hematopoiesis and hypercellular bone marrow. Several genetic alterations have been reported in MDS but these are not MDS-specific and the underlying molecular causes of the disease remain poorly understood. Gene expression microarray technology allows the simultaneous parallel analysis of many thousands of genes and has already provided novel insights into cancer pathogenesis. In this review we discuss the results of several recent studies which utilize the enormous power of microarray technology for the study of MDS. Several exciting findings have emerged from these early studies that highlight the potential of this technology to further our understanding of the molecular pathogenesis of this disorder. It is clear, however, that these findings should be confirmed in larger sets of MDS patients.
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spelling oxford-uuid:13b36e26-434b-4bbf-8043-a8fa2016cf8f2022-03-26T10:15:20ZGene expression profiling in the myelodysplastic syndromes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:13b36e26-434b-4bbf-8043-a8fa2016cf8fEnglishSymplectic Elements at Oxford2005Pellagatti, AFidler, CWainscoat, JBoultwood, JThe myelodysplastic syndromes (MDS) are a heterogeneous group of haematopoietic malignancies, characterized by blood cytopenias, ineffective hematopoiesis and hypercellular bone marrow. Several genetic alterations have been reported in MDS but these are not MDS-specific and the underlying molecular causes of the disease remain poorly understood. Gene expression microarray technology allows the simultaneous parallel analysis of many thousands of genes and has already provided novel insights into cancer pathogenesis. In this review we discuss the results of several recent studies which utilize the enormous power of microarray technology for the study of MDS. Several exciting findings have emerged from these early studies that highlight the potential of this technology to further our understanding of the molecular pathogenesis of this disorder. It is clear, however, that these findings should be confirmed in larger sets of MDS patients.
spellingShingle Pellagatti, A
Fidler, C
Wainscoat, J
Boultwood, J
Gene expression profiling in the myelodysplastic syndromes.
title Gene expression profiling in the myelodysplastic syndromes.
title_full Gene expression profiling in the myelodysplastic syndromes.
title_fullStr Gene expression profiling in the myelodysplastic syndromes.
title_full_unstemmed Gene expression profiling in the myelodysplastic syndromes.
title_short Gene expression profiling in the myelodysplastic syndromes.
title_sort gene expression profiling in the myelodysplastic syndromes
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