Prevalence of radiographic hip osteoarthritis is increased in high bone mass.
OBJECTIVE: Epidemiological studies have shown an association between increased bone mineral density (BMD) and osteoarthritis (OA), but whether this represents cause or effect remains unclear. In this study, we used a novel approach to investigate this question, determining whether individuals with H...
| Asıl Yazarlar: | , , , , , , , , , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Elsevier
2014
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| _version_ | 1826260201828777984 |
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| author | Hardcastle, SA Dieppe, P Gregson, C Hunter, D Thomas, G Arden, N Spector, T Hart, D Laugharne, M Clague, G Edwards, M Dennison, E Cooper, C Williams, M Davey Smith, G Tobias, J |
| author_facet | Hardcastle, SA Dieppe, P Gregson, C Hunter, D Thomas, G Arden, N Spector, T Hart, D Laugharne, M Clague, G Edwards, M Dennison, E Cooper, C Williams, M Davey Smith, G Tobias, J |
| author_sort | Hardcastle, SA |
| collection | OXFORD |
| description | OBJECTIVE: Epidemiological studies have shown an association between increased bone mineral density (BMD) and osteoarthritis (OA), but whether this represents cause or effect remains unclear. In this study, we used a novel approach to investigate this question, determining whether individuals with High Bone Mass (HBM) have a higher prevalence of radiographic hip OA compared with controls. DESIGN: HBM cases came from the UK-based HBM study: HBM was defined by BMD Z-score. Unaffected relatives of index cases were recruited as family controls. Age-stratified random sampling was used to select further population controls from the Chingford and Hertfordshire cohort studies. Pelvic radiographs were pooled and assessed by a single observer blinded to case-control status. Analyses used logistic regression, adjusted for age, gender and body mass index (BMI). RESULTS: 530 HBM hips in 272 cases (mean age 62.9 years, 74% female) and 1702 control hips in 863 controls (mean age 64.8 years, 84% female) were analysed. The prevalence of radiographic OA, defined as Croft score ≥3, was higher in cases compared with controls (20.0% vs 13.6%), with adjusted odds ratio (OR) [95% CI] 1.52 [1.09, 2.11], P = 0.013. Osteophytes (OR 2.12 [1.61, 2.79], P < 0.001) and subchondral sclerosis (OR 2.78 [1.49, 5.18], P = 0.001) were more prevalent in cases. However, no difference in the prevalence of joint space narrowing (JSN) was seen (OR 0.97 [0.72, 1.33], P = 0.869). CONCLUSIONS: An increased prevalence of radiographic hip OA and osteophytosis was observed in HBM cases compared with controls, in keeping with a positive association between HBM and OA and suggesting that OA in HBM has a hypertrophic phenotype. |
| first_indexed | 2024-03-06T19:01:53Z |
| format | Journal article |
| id | oxford-uuid:13d3d0fa-ce07-4a9e-8d3c-8b91b22e627d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:01:53Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:13d3d0fa-ce07-4a9e-8d3c-8b91b22e627d2022-03-26T10:16:02ZPrevalence of radiographic hip osteoarthritis is increased in high bone mass.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:13d3d0fa-ce07-4a9e-8d3c-8b91b22e627dEnglishSymplectic Elements at OxfordElsevier2014Hardcastle, SADieppe, PGregson, CHunter, DThomas, GArden, NSpector, THart, DLaugharne, MClague, GEdwards, MDennison, ECooper, CWilliams, MDavey Smith, GTobias, JOBJECTIVE: Epidemiological studies have shown an association between increased bone mineral density (BMD) and osteoarthritis (OA), but whether this represents cause or effect remains unclear. In this study, we used a novel approach to investigate this question, determining whether individuals with High Bone Mass (HBM) have a higher prevalence of radiographic hip OA compared with controls. DESIGN: HBM cases came from the UK-based HBM study: HBM was defined by BMD Z-score. Unaffected relatives of index cases were recruited as family controls. Age-stratified random sampling was used to select further population controls from the Chingford and Hertfordshire cohort studies. Pelvic radiographs were pooled and assessed by a single observer blinded to case-control status. Analyses used logistic regression, adjusted for age, gender and body mass index (BMI). RESULTS: 530 HBM hips in 272 cases (mean age 62.9 years, 74% female) and 1702 control hips in 863 controls (mean age 64.8 years, 84% female) were analysed. The prevalence of radiographic OA, defined as Croft score ≥3, was higher in cases compared with controls (20.0% vs 13.6%), with adjusted odds ratio (OR) [95% CI] 1.52 [1.09, 2.11], P = 0.013. Osteophytes (OR 2.12 [1.61, 2.79], P < 0.001) and subchondral sclerosis (OR 2.78 [1.49, 5.18], P = 0.001) were more prevalent in cases. However, no difference in the prevalence of joint space narrowing (JSN) was seen (OR 0.97 [0.72, 1.33], P = 0.869). CONCLUSIONS: An increased prevalence of radiographic hip OA and osteophytosis was observed in HBM cases compared with controls, in keeping with a positive association between HBM and OA and suggesting that OA in HBM has a hypertrophic phenotype. |
| spellingShingle | Hardcastle, SA Dieppe, P Gregson, C Hunter, D Thomas, G Arden, N Spector, T Hart, D Laugharne, M Clague, G Edwards, M Dennison, E Cooper, C Williams, M Davey Smith, G Tobias, J Prevalence of radiographic hip osteoarthritis is increased in high bone mass. |
| title | Prevalence of radiographic hip osteoarthritis is increased in high bone mass. |
| title_full | Prevalence of radiographic hip osteoarthritis is increased in high bone mass. |
| title_fullStr | Prevalence of radiographic hip osteoarthritis is increased in high bone mass. |
| title_full_unstemmed | Prevalence of radiographic hip osteoarthritis is increased in high bone mass. |
| title_short | Prevalence of radiographic hip osteoarthritis is increased in high bone mass. |
| title_sort | prevalence of radiographic hip osteoarthritis is increased in high bone mass |
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