Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent immunosuppression with increased risk of recurrent infections. We utilized the cecal ligation and puncture (CLP) model of...

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Bibliographische Detailangaben
Hauptverfasser: Nascimento, DC, Viacava, PR, Ferreira, RG, Damaceno, MA, Piñeros, AR, Melo, PH, Donate, PB, Toller-Kawahisa, JE, Zoppi, D, Veras, FP, Peres, RS, Menezes-Silva, L, Caetité, D, Oliveira, AER, Castro, ÍMS, Kauffenstein, G, Nakaya, HI, Borges, MC, Zamboni, DS, Fonseca, DM, Paschoal, JAR, Cunha, TM, Quesniaux, V, Linden, J, Cunha, FQ, Ryffel, B, Alves-Filho, JC
Format: Journal article
Sprache:English
Veröffentlicht: Cell Press 2021

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