Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent immunosuppression with increased risk of recurrent infections. We utilized the cecal ligation and puncture (CLP) model of...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Nascimento, DC, Viacava, PR, Ferreira, RG, Damaceno, MA, Piñeros, AR, Melo, PH, Donate, PB, Toller-Kawahisa, JE, Zoppi, D, Veras, FP, Peres, RS, Menezes-Silva, L, Caetité, D, Oliveira, AER, Castro, ÍMS, Kauffenstein, G, Nakaya, HI, Borges, MC, Zamboni, DS, Fonseca, DM, Paschoal, JAR, Cunha, TM, Quesniaux, V, Linden, J, Cunha, FQ, Ryffel, B, Alves-Filho, JC
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: Cell Press 2021

Samankaltaisia teoksia

Samankaltaisia teoksia