Phentolamine block of KATP channels is mediated by Kir6.2.
The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus, thereby initiating a membrane depolarization that...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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