Phentolamine block of KATP channels is mediated by Kir6.2.

Phentolamine block of KATP channels is mediated by Kir6.2.

The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus, thereby initiating a membrane depolarization that...

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Bibliographic Details
Main Authors:	Proks, P, Ashcroft, F
Format:	Journal article
Language:	English
Published:	1997

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