Consensus classification of posterior cortical atrophy
<h4>Introduction</h4> <p>A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.</p> <h4>Methods</h4> <p>Consensus statements about PCAwere develo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2017
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| _version_ | 1826260262748946432 |
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| author | Crutch, S Schott, J Rabinovici, G Murray, M Snowden, J , v Dickerson, B Vandenberghe, R Ahmed, S Bak, T Boeve, B Butler, C Cappa, S Ceccaldi, M de Souza, L Dubois, B Felician, O Galasko, D Graff-Radford, J Graff-Radford, N Hof, P Krolak-Salmon, P Lehmann, M Magnin, E Mendez, M Nestor, P Onyike, C Pelak, V Pijnenburg, Y Primativo, S Rossor, M Ryan, N Scheltens, P Shakespeare, T Suárez González, A Tang-Wai, D Yong, K Carrillo, M Fox, N |
| author_facet | Crutch, S Schott, J Rabinovici, G Murray, M Snowden, J , v Dickerson, B Vandenberghe, R Ahmed, S Bak, T Boeve, B Butler, C Cappa, S Ceccaldi, M de Souza, L Dubois, B Felician, O Galasko, D Graff-Radford, J Graff-Radford, N Hof, P Krolak-Salmon, P Lehmann, M Magnin, E Mendez, M Nestor, P Onyike, C Pelak, V Pijnenburg, Y Primativo, S Rossor, M Ryan, N Scheltens, P Shakespeare, T Suárez González, A Tang-Wai, D Yong, K Carrillo, M Fox, N |
| author_sort | Crutch, S |
| collection | OXFORD |
| description | <h4>Introduction</h4> <p>A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.</p> <h4>Methods</h4> <p>Consensus statements about PCAwere developed through a detailed literature review, the formation of an international multidisciplinary working party which convened on four occasions, and a Web-based quantitative survey regarding symptom frequency and the conceptualization of PCA.</p> <h4>Results</h4> <p>A three-level classification framework for PCA is described comprising both syndromeand disease-level descriptions. Classification level 1 (PCA) defines the core clinical, cognitive, and neuroimaging features and exclusion criteria of the clinico-radiological syndrome. Classification level 2 (PCA-pure, PCA-plus) establishes whether, in addition to the core PCA syndrome, the core features of any other neurodegenerative syndromes are present. Classification level 3 (PCA attributable to AD [PCA-AD], Lewy body disease [PCA-LBD], corticobasal degeneration [PCA-CBD], prion disease [PCA-prion]) provides a more formal determination of the underlying cause of the PCA syndrome, based on available pathophysiological biomarker evidence. The issue of additional syndrome-level descriptors is discussed in relation to the challenges of defining stages of syndrome severity and characterizing phenotypic heterogeneity within the PCA spectrum.</p> <h4>Discussion</h4> <p>There was strong agreement regarding the definition of the core clinico-radiological syndrome, meaning that the current consensus statement should be regarded as a refinement, development, and extension of previous single-center PCA criteria rather than any wholesale alteration or redescription of the syndrome. The framework and terminology may facilitate the interpretation of research data across studies, be applicable across a broad range of research scenarios (e.g., behavioral interventions, pharmacological trials), and provide a foundation for future collaborative work.</p> |
| first_indexed | 2024-03-06T19:02:53Z |
| format | Journal article |
| id | oxford-uuid:1426a133-8096-4a7c-bba0-af963c63d60a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:02:53Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:1426a133-8096-4a7c-bba0-af963c63d60a2022-03-26T10:18:03ZConsensus classification of posterior cortical atrophyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1426a133-8096-4a7c-bba0-af963c63d60aEnglishSymplectic Elements at OxfordElsevier2017Crutch, SSchott, JRabinovici, GMurray, MSnowden, J, vDickerson, BVandenberghe, RAhmed, SBak, TBoeve, BButler, CCappa, SCeccaldi, Mde Souza, LDubois, BFelician, OGalasko, DGraff-Radford, JGraff-Radford, NHof, PKrolak-Salmon, PLehmann, MMagnin, EMendez, MNestor, POnyike, CPelak, VPijnenburg, YPrimativo, SRossor, MRyan, NScheltens, PShakespeare, TSuárez González, ATang-Wai, DYong, KCarrillo, MFox, N <h4>Introduction</h4> <p>A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.</p> <h4>Methods</h4> <p>Consensus statements about PCAwere developed through a detailed literature review, the formation of an international multidisciplinary working party which convened on four occasions, and a Web-based quantitative survey regarding symptom frequency and the conceptualization of PCA.</p> <h4>Results</h4> <p>A three-level classification framework for PCA is described comprising both syndromeand disease-level descriptions. Classification level 1 (PCA) defines the core clinical, cognitive, and neuroimaging features and exclusion criteria of the clinico-radiological syndrome. Classification level 2 (PCA-pure, PCA-plus) establishes whether, in addition to the core PCA syndrome, the core features of any other neurodegenerative syndromes are present. Classification level 3 (PCA attributable to AD [PCA-AD], Lewy body disease [PCA-LBD], corticobasal degeneration [PCA-CBD], prion disease [PCA-prion]) provides a more formal determination of the underlying cause of the PCA syndrome, based on available pathophysiological biomarker evidence. The issue of additional syndrome-level descriptors is discussed in relation to the challenges of defining stages of syndrome severity and characterizing phenotypic heterogeneity within the PCA spectrum.</p> <h4>Discussion</h4> <p>There was strong agreement regarding the definition of the core clinico-radiological syndrome, meaning that the current consensus statement should be regarded as a refinement, development, and extension of previous single-center PCA criteria rather than any wholesale alteration or redescription of the syndrome. The framework and terminology may facilitate the interpretation of research data across studies, be applicable across a broad range of research scenarios (e.g., behavioral interventions, pharmacological trials), and provide a foundation for future collaborative work.</p> |
| spellingShingle | Crutch, S Schott, J Rabinovici, G Murray, M Snowden, J , v Dickerson, B Vandenberghe, R Ahmed, S Bak, T Boeve, B Butler, C Cappa, S Ceccaldi, M de Souza, L Dubois, B Felician, O Galasko, D Graff-Radford, J Graff-Radford, N Hof, P Krolak-Salmon, P Lehmann, M Magnin, E Mendez, M Nestor, P Onyike, C Pelak, V Pijnenburg, Y Primativo, S Rossor, M Ryan, N Scheltens, P Shakespeare, T Suárez González, A Tang-Wai, D Yong, K Carrillo, M Fox, N Consensus classification of posterior cortical atrophy |
| title | Consensus classification of posterior cortical atrophy |
| title_full | Consensus classification of posterior cortical atrophy |
| title_fullStr | Consensus classification of posterior cortical atrophy |
| title_full_unstemmed | Consensus classification of posterior cortical atrophy |
| title_short | Consensus classification of posterior cortical atrophy |
| title_sort | consensus classification of posterior cortical atrophy |
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