Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.
A series of neoglycoconjugates derived from deoxynojirimycin has been prepared by click connection with functionalised adamantanes. They have been assayed as glycosidase inhibitors, as inhibitors of the glycoenzymes relevant to the treatment of Gaucher disease, as well as correctors of the defective...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1797054857633333248 |
|---|---|
| author | Ardes-Guisot, N Alonzi, D Reinkensmeier, G Butters, T Norez, C Becq, F Shimada, Y Nakagawa, S Kato, A Blériot, Y Sollogoub, M Vauzeilles, B |
| author_facet | Ardes-Guisot, N Alonzi, D Reinkensmeier, G Butters, T Norez, C Becq, F Shimada, Y Nakagawa, S Kato, A Blériot, Y Sollogoub, M Vauzeilles, B |
| author_sort | Ardes-Guisot, N |
| collection | OXFORD |
| description | A series of neoglycoconjugates derived from deoxynojirimycin has been prepared by click connection with functionalised adamantanes. They have been assayed as glycosidase inhibitors, as inhibitors of the glycoenzymes relevant to the treatment of Gaucher disease, as well as correctors of the defective ion-transport protein involved in cystic fibrosis. We have demonstrated that it is possible to selectively either strongly inhibit ER-α-glucosidases and ceramide glucosyltransferase or restore the activity of CFTR in CF-KM4 cells by varying the length of the alkyl chain linking DNJ and adamantane. |
| first_indexed | 2024-03-06T19:03:13Z |
| format | Journal article |
| id | oxford-uuid:144012ed-3879-4549-a57e-1b3b9d7f5e5b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:03:13Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:144012ed-3879-4549-a57e-1b3b9d7f5e5b2022-03-26T10:18:38ZSelection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:144012ed-3879-4549-a57e-1b3b9d7f5e5bEnglishSymplectic Elements at Oxford2011Ardes-Guisot, NAlonzi, DReinkensmeier, GButters, TNorez, CBecq, FShimada, YNakagawa, SKato, ABlériot, YSollogoub, MVauzeilles, BA series of neoglycoconjugates derived from deoxynojirimycin has been prepared by click connection with functionalised adamantanes. They have been assayed as glycosidase inhibitors, as inhibitors of the glycoenzymes relevant to the treatment of Gaucher disease, as well as correctors of the defective ion-transport protein involved in cystic fibrosis. We have demonstrated that it is possible to selectively either strongly inhibit ER-α-glucosidases and ceramide glucosyltransferase or restore the activity of CFTR in CF-KM4 cells by varying the length of the alkyl chain linking DNJ and adamantane. |
| spellingShingle | Ardes-Guisot, N Alonzi, D Reinkensmeier, G Butters, T Norez, C Becq, F Shimada, Y Nakagawa, S Kato, A Blériot, Y Sollogoub, M Vauzeilles, B Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. |
| title | Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. |
| title_full | Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. |
| title_fullStr | Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. |
| title_full_unstemmed | Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. |
| title_short | Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. |
| title_sort | selection of the biological activity of dnj neoglycoconjugates through click length variation of the side chain |
| work_keys_str_mv | AT ardesguisotn selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT alonzid selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT reinkensmeierg selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT butterst selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT norezc selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT becqf selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT shimaday selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT nakagawas selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT katoa selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT blerioty selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT sollogoubm selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain AT vauzeillesb selectionofthebiologicalactivityofdnjneoglycoconjugatesthroughclicklengthvariationofthesidechain |