Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.

A series of neoglycoconjugates derived from deoxynojirimycin has been prepared by click connection with functionalised adamantanes. They have been assayed as glycosidase inhibitors, as inhibitors of the glycoenzymes relevant to the treatment of Gaucher disease, as well as correctors of the defective...

Full description

Bibliographic Details
Main Authors:	Ardes-Guisot, N, Alonzi, D, Reinkensmeier, G, Butters, T, Norez, C, Becq, F, Shimada, Y, Nakagawa, S, Kato, A, Blériot, Y, Sollogoub, M, Vauzeilles, B
Format:	Journal article
Language:	English
Published:	2011

Similar Items

Design and synthesis of multivalent neoglycoconjugates by click conjugations
by: Ding, Feiqing, et al.
Published: (2014)

Towards a stable noeuromycin analog with a d-manno configuration: Synthesis and glycosidase inhibition of d-manno-like tri- and tetrahydroxylated azepanes
by: Deschamp, J, et al.
Published: (2010)

Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes.
by: Deschamp, J, et al.
Published: (2012)

Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars
by: Best, D, et al.
Published: (2010)

Recent progress in the field of neoglycoconjugate chemistry
by: Jiménez-Castells Carmen, et al.
Published: (2010-05-01)

Neoglycoconjugates for the delivery of nucleic acids into eucaryotic cells
by: M. A. Maslov, et al.
Published: (2015-08-01)

Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells
by: Perera, N, et al.
Published: (2022)

C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.
by: Jenkinson, S, et al.
Published: (2013)

4-C-Me-DAB and 4-C-Me-LAB-enantiomeric alkyl-branched pyrrolidine iminosugars-are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group
by: Cruz, F, et al.
Published: (2010)

Active derivatives based on D-galactose and D-lactose in synthesis of neoglycoconjugates
by: L. Yu. Guryeva, et al.
Published: (2006-08-01)

ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting anti-flaviviral activity
by: Kiappes, JL, et al.
Published: (2017)

4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.
by: da Cruz, F, et al.
Published: (2011)

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.
by: Désiré, J, et al.
Published: (2014)

Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells.
by: Butters, T, et al.
Published: (2009)

Synthesis of trisaccharides incorporating the α-Gal antigen functionalized for neoglycoconjugate preparation
by: Patrice Plaza-Alexander, et al.
Published: (2012-10-01)

Preparation of selectively protected protoescigenin derivatives for synthesis of escin analogs and neoglycoconjugates
by: Jatczak Kamil, et al.
Published: (2014-12-01)

Iminosugar NB-DNJ delays mortality in lethal model of dengue virus infection in mice
by: Beatty, P, et al.
Published: (2009)

Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90
by: Lukas Schmauder, et al.
Published: (2021-11-01)

Pathogen-induced inflammation is attenuated by the iminosugar MON-DNJ via modulation of the unfolded protein response
by: Sayce, AC, et al.
Published: (2021)

Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: potent and selective beta-N-acetylhexosaminidase inhibitors.
by: Li, H, et al.
Published: (2009)

Mining and functional characterization of NADPH-cytochrome P450 reductases of the DNJ biosynthetic pathway in mulberry leaves
by: Yangzhen Liao, et al.
Published: (2024-02-01)

Dnj1 Promotes Virulence in Cryptococcus neoformans by Maintaining Robust Endoplasmic Reticulum Homeostasis Under Temperature Stress
by: Linda C. Horianopoulos, et al.
Published: (2021-09-01)

Urinary glycan markers for disease.
by: Alonzi, D, et al.
Published: (2011)

Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-L-bulgecinine from D-glucuronolactone and of L-DNJ, L-DMDP, and (3S)-3-hydroxy-D-bulgecinine from L-glucuronolactone. DMDP inhibits beta-glucosidases and beta-galactosidases whereas L-DMDP is a potent and specific inhibitor of alpha-glucosidases
by: Best, D, et al.
Published: (2010)

Therapeutic targets for inhibitors of glycosylation.
by: Alonzi, D, et al.
Published: (2011)

A Neoglycoconjugate Containing the Human Milk Sugar LNFPIII Drives Anti-Inflammatory Activation of Antigen Presenting Cells in a CD14 Dependent Pathway.
by: Smanla Tundup, et al.
Published: (2015-01-01)

Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model
by: Seika Takayanagi-Kiya, et al.
Published: (2016-07-01)

Rapid and Specific Enrichment of Culturable Gram Negative Bacteria Using Non-Lethal Copper-Free Click Chemistry Coupled with Magnetic Beads Separation.
by: Emilie Fugier, et al.
Published: (2015-01-01)

Synthesis and characterization of poly(vinylchloride) type macrophotoinitiator comprising side-chain thioxanthone via click chemistry
Published: (2011-04-01)

Determination of 1-Deoxynojirimycin (1-DNJ) in Leaves of Italian or Italy-Adapted Cultivars of Mulberry (<i>Morus</i> sp.pl.) by HPLC-MS
by: Lucia Marchetti, et al.
Published: (2021-07-01)

GmDNJ1, a type‐I heat shock protein 40 (HSP40), is responsible for both Growth and heat tolerance in soybean
by: Kwan‐Pok Li, et al.
Published: (2021-01-01)

The mulberry-derived 1-deoxynojirimycin (DNJ) inhibits high-fat diet (HFD)-induced hypercholesteremia and modulates the gut microbiota in a gender-specific manner
by: Yougui Li, et al.
Published: (2019-01-01)

Click here to buy. Click here to vote.
by: Mary Ingram-Waters
Published: (2020-03-01)

AutoClickChem: click chemistry in silico.
by: Jacob D Durrant, et al.
Published: (2012-01-01)

CFTR and Ca2+ signaling in cystic fibrosis
by: Fabrice eAntigny, et al.
Published: (2011-10-01)

Carbasugar-thioether pseudodisaccharides related to N-glycan biosynthesis.
by: Cumpstey, I, et al.
Published: (2009)

Improved cellular inhibitors for glycoprotein processing alpha-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins
by: Alonzi, D, et al.
Published: (2009)

Hydrophilic interaction liquid chromatography of anthranilic acid-labelled oligosaccharides with a 4-aminobenzoic acid ethyl ester-labelled dextran hydrolysate internal standard.
by: Neville, D, et al.
Published: (2012)

Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors.
by: Yeoh, K, et al.
Published: (2009)

Side-Chain Length and Dispersity in ROMP Polymers with Pore-Generating Side Chains for Gas Separations
by: Benedetti, Francesco M, et al.
Published: (2022)